Results 61 to 70 of about 23,466 (213)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

UMA ANÁLISE DE MÉTRICAS DE SOFTWARE ORIENTADAS À FUNÇÃO E SUA APLICAÇÃO AO DESENVOLVIMENTO ORIENTADO A OBJETOS

Vértices, 2010
Este artigo visa a efetuar uma abordagem da mensuração de softwares através da metodologia de Pontos por Função, partindo de aspectos históricos, demonstrando seu funcionamento e analisando sua possível aplicação em softwares desenvolvidos dentro do ...
Everton Alves Miranda
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Vocabulary instruction through blended learning and multimedia softwares in Iranian ESP classes [PDF]

Journal of English Language Teaching and Learning, 2015
The purpose of this study was to investigate the impact of blended learning and multimedia softwares on Iranian ESP students' vocabulary learning. To this end, 120 Iranian ESP learners were assigned to two groups: the experimental and control groups. The
Sadegh Khalili, Mohammad Hassan Tahririan, Setareh Bagheri   +2 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Análise dos modelos colaborativos de softwares para edição de ontologias por meio do Modelo 4C de Colaboração

Em Questão, 2019
Esta pesquisa objetiva apresentar os modelos de colaboração de seis softwares editores de ontologia: MusicBrainz, OntoWiki, Semantic MediaWiki, Tainacan Ontology, WebProtégé e Wikidata, e relacionar as ferramentas para colaboração disponíveis ...
Marcel Ferrante Silva, Dalton Lopes Martins , Joyce Siqueira, Douglas Veronez Santana   +3 more
doaj   +1 more source

ANÁLISE DE SOFTWARES DE GESTÃO DA PECUÁRIA DE CORTE SOB A PERSPECTIVA DA QUALIDADE DE SOFTWARE

Revista Brasileira de Engenharia de Biossistemas, 2011
O objetivo dessa pesquisa é avaliar os principais softwares de gestão administrativa no âmbito da pecuária de corte, a partir da metodologia proposta por Campos (2001).
Daniel Manzano JORGE, João Guilherme de Camargo Ferraz MACHADO   +1 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A CASE STUDY OF MODELING A TORUS IN DIFFERENT MODELING SOFTWARES

Journal of Industrial Design and Engineering Graphics, 2017
Modeling of the complex geometric shapes requires the use of appropriate softwares. This study analyzes the process of modeling with two different computer softwares, AutoCAD and Rhinoceros.
VELJKOVIĆ Milica, KRASIĆ Sonja, PEJIĆ Petar, TOŠIĆ Zlata   +3 more
doaj