Results 71 to 80 of about 74,815 (272)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Análise do uso de softwares de simulação termoenergéticas em edificações

open access: yes, 2020
ArtigoAs simulações são saídas ainda pouco utilizadas para previsões de situações ocasionadas na construção civil. Realizou-se um estudo bibliográfico sobre a utilização de softwares de simulação termoenergéticas, a fim de quantificar o conforto ...
Medeiros, Maria Mariana Xavier de Lima
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The Rate of Using Citation Management Softwares in Available Databases of Tehran University of Medical Sciences

open access: yesمجله علم‌سنجی کاسپین, 2016
Background and aim: Nowadays, many of the databases provide Citation Management Softwares for researchers in order to facilitate the research. The purpose of this study ‌was ‌to determine the rate of using citation management softwares in available ...
elahe Ommati, Fereydoon Azadeh
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Softwares em humanidades digitais: potencialidades e limitações metodológicas na pesquisa social com resgate de notícias da web

open access: yesAcervo, 2022
Este artigo aborda potencialidades e limitações de softwares empregados na pesquisa social para coleta, sistematização, análise e visualização de dados com resgate de páginas na web (notícias).
Cristiane Naiara Araujo de Souza   +1 more
doaj   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Approaching children of primary school with Marti anti-imperialist thinking through educational softwares Multisaber Collection

open access: yesRevista MENDIVE, 2005
The authors staff prepared a series of activities using educational softwares for the development of the ideological political preparation, apart from the planning of classes with educational softwares and softwares taken as models and examples so that ...
Ada Bonilla Vichot   +2 more
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Numerical Analysis in Econom(etr)ic Softwares: the Data-Memory Shortage Management [PDF]

open access: yes
The econometricians and the economic modelers have to know and use numerical analysis not only to have a good understanding of their results, but sometimes to built their own tools.
Buda, Rodolphe
core  

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