Results 91 to 100 of about 6,448,115 (298)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Development of a molecularly imprinted solid phase extraction sorbent for the selective removal of rivastigmine from serum samples

Reviews in Analytical Chemistry
A molecularly imprinted solid-phase extraction (MISPE) sorbent has been developed for the separation of RIV from serum sample. Molecularly imprinted polymer (MIP) was prepared via non-covalent imprinting technique using RIV as a template molecule ...
Yıldız Merve, Yılmaz Hüma, Basan Hasan   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Otimização e aplicação da microextração em fase sólida com e sem refrigeração interna em amostras de ervas medicinais e água de rio [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Quimica, Florianópolis, 2013A microextração em fase sólida no modo de extração headspace (HS-SPME) e a microextração ...
Merib, Josias de Oliveira
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

MODELLING OF SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA LEAVES BY EMPLOYING INTEGRAL DESORPTION CONCEPT [PDF]

, 2006
Mathematical formulation is necessary for the optimisation and scale-up of a separation unit such as the extraction of biomolecules from their natural resources.
Kumoro, A.C., Hasan, M., Kumoro, Andri Cahyo   +2 more
core   +2 more sources

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Spöhrer, Ute, Schiel, Xaver, Vogeser, Michael   +2 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

EFFECT OF SOLVENT FLOW RATE ON THE SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANDROGRAPHOLIDE FROM ANDROGRAPHIS PANICULATA [PDF]

, 2006
Malaysia is one of the major medicinal plants (Andrographis paniculata) producers in the world. Extraction of bioactive component (andrographolide) from ground dried leaves of this plant using supercritical carbon dioxide has been studied.
Kumoro, A.C., Hasan, M.
core   +1 more source