Results 41 to 50 of about 277,049 (293)
Acta Pharmaceutica Sinica B, 2016 Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing.
Jie Peng +7 more
doaj +1 more source
OligoHydrogelArray (OHA) for Parallelized Solid‐Phase Extraction of Oligonucleotides
Advanced Materials Interfaces, 2023 Immobilization of oligonucleotides on solid surfaces is an important step in many experimental workflows in biology, such as gene expression analysis, genotyping, and drug discoveries.
Michelle J. Iwohn +7 more
doaj +1 more source
Separations, 2022 Pyrrolizidine alkaloids are plant secondary metabolites that have recently attracted attention as toxic contaminants in various foods and feeds as they are often harvested by accident.
Tobias Schlappack +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Considerações sobre o preparo de amostras contendo micropoluentes estrogênicos
Química Nova, 2012 In this work, the materials used in the recovery of estrogens from aqueous matrices by filtration and solid phase extraction were evaluated. The results showed that glass-fiber filters allow a recovery and repeatability compatible with this type of ...
Marcus Vinicius de Liz +2 more
doaj +1 more source
Electrospun Nanofiber Based Solid Phase Extraction [PDF]
TrAC Trends in Analytical Chemistry, 2012 Abstract The article discusses theoretical and experimental aspects of fabricating devices and developing methods for electrospun nanofiber-based solid-phase extraction (SPE). It seeks to encourage a better understanding of the use of electrospun nanofibers as a chromatographic sorbent bed.
Chigome, Samuel, Torto, Nelson
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Recovery of gangliosides from aqueous solutions on styrene-divinylbenzene copolymer columns1
Journal of Lipid Research, 2002 An investigation was made using a styrene-divinylbenzene copolymer as a solid phase sorbent to recover gangliosides from aqueous solutions. A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides ...
Iuliana Popa +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source