Results 41 to 50 of about 19,533,251 (282)

Solid-state additive manufacturing for metallized optical fiber integration [PDF]

Composites Part A: Applied Science and Manufacturing, 2015
AbstractThe formation of smart, Metal Matrix Composite (MMC) structures through the use of solid-state Ultrasonic Additive Manufacturing (UAM) is currently hindered by the fragility of uncoated optical fibers under the required processing conditions. In this work, optical fibers equipped with metallic coatings were fully integrated into solid Aluminum ...
Monaghan, T, Capel, AJ, Christie, SD, Harris, RA, Friel, RJ   +4 more
openaire   +2 more sources

Additive friction stir deposition of AZ31B magnesium alloy

Journal of Magnesium and Alloys, 2022
The current work explored additive friction stir deposition of AZ31B magnesium alloy with the aid of MELD® technology. AZ31B magnesium bar stock was fed through a hollow friction stir tool rotating at constant velocity of 400 rpm and translating at ...
Sameehan S. Joshi, Shreyash M. Patil, Sangram Mazumder, Shashank Sharma, Daniel A. Riley, Shelden Dowden, Rajarshi Banerjee, Narendra B. Dahotre   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Binder jet additive manufacturing method to fabricate near net shape crack-free highly dense Fe-6.5 wt.% Si soft magnets

Heliyon, 2019
High silicon (Si) electrical steel has the potential for efficient use in applications such as electrical motors and generators with cost-effective in processing, but it is difficult to manufacture.
Corson L. Cramer, Peeyush Nandwana, Jiaqiang Yan, Samuel F. Evans, Amy M. Elliott, Chins Chinnasamy, M. Parans Paranthaman   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Impact of Native Oxides on Bonding Interface Microstructure in Deformation‐Based Solid‐State Additive Manufacturing

cMat
In solid‐state metal additive manufacturing, oxide removal is crucial for high‐quality bonding, yet its impact remains unclear. In the article, the influence of oxides on the bonding interface by using cold spray additive manufacturing and leveraging ...
Pengfei Yu, Ningsong Fan, Wenya Li, Chunjie Huang, Yaxin Xu, Jianfeng Wang, Zhaoguo Qiu, Rocco Lupoi, Shuo Yin   +8 more
doaj   +1 more source

Feasibility of multilayer solid-state deposition via lateral friction surfacing for metal additive manufacturing

Journal of Materials Research and Technology, 2022
Lateral friction surfacing is a novel solid-state deposition process in which the radial surface of the rotating consumable tool is forced into the substrate surface, facilitating material transfer.
Ebrahim Seidi, Scott F. Miller
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source