Results 41 to 50 of about 20,335,239 (286)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Simulation of additive manufacturing using coupled constitutive and microstructure models
, 2016 The paper describes the application of modeling approaches used in Computational Welding Mechanics (CWM) applicable for simulating Additive Manufacturing (AM).
Lindgren, Lars-Erik, +4 more
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Heliyon, 2019 High silicon (Si) electrical steel has the potential for efficient use in applications such as electrical motors and generators with cost-effective in processing, but it is difficult to manufacture.
Corson L. Cramer +6 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Thermo-mechanical analysis of wire and arc additive manufacturing process [PDF]
, 2012 Conventional manufacturing processes often require a large amount of machining and cannot satisfy the continuously increasing requirements of a sustainable, low cost, and environmentally friendly modern industry.
Ding, Jialuo
core +3 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
cMatIn solid‐state metal additive manufacturing, oxide removal is crucial for high‐quality bonding, yet its impact remains unclear. In the article, the influence of oxides on the bonding interface by using cold spray additive manufacturing and leveraging ...
Pengfei Yu +8 more
doaj +1 more source
Journal of Materials Research and Technology, 2022 Lateral friction surfacing is a novel solid-state deposition process in which the radial surface of the rotating consumable tool is forced into the substrate surface, facilitating material transfer.
Ebrahim Seidi, Scott F. Miller
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source