Results 51 to 60 of about 19,533,251 (282)

Friction-forging tubular additive manufacturing (FFTAM): A new route of solid-state layer-upon-layer metal deposition

Journal of Materials Research and Technology, 2020
A new solid-state 3D-printing technology based on the friction-stir processing (FSP) treatment and forging consolidation is examined here for additive manufacturing (AM) to produce the tubular components in a layer-by-layer method, yielding extremely ...
H. Aghajani Derazkola, F. Khodabakhshi, A.P. Gerlich   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Progress in cold spray solid-state deposition additive manufacturing technology

Review of Materials Research
As an emerging solid-state material deposition method, cold spray technology enables the deposition of metals in the solid state through the high-velocity impact (300-1200 m/s) of micron-sized powder particles (5-50 μm), avoiding the composition changes ...
Jihao Shen, Jun Wang, Yan Wang, XiaoTao Luo, Chang-Jiu Li   +4 more
doaj   +1 more source

Additive manufacturing and high performance applications

, 2018
The requirement on life and robustness for aero-engine components poses obstacles to additive manufacturing. It is expected that increasing knowledge about the process and thereby its development together with adaption of existing alloys may improve ...
Lindgren, Lars-Erik,, Lundbäck, Andreas,, Lindgren, Lars-Erik, Lundbӓck, Andreas   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Review on Solid-State-Based Additive Friction Stir Deposition

Aerospace, 2022
Additive manufacturing (AM) is an important technology in Industry 4.0. In recent years, solid-state-based additive friction stir deposition (AFSD) has attracted much attention, as it can avoid the inherent defect of melting and rapid solidification in ...
Hongrui Dong, Xiaoqiang Li, Ke Xu, Zhenyu Zang, Xin Liu, Zongjiang Zhang, Wenlong Xiao, Yong Li   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Incremental solidification (toward 3D-printing) of metal powders by transistor-based microwave applicator

Materials & Design, 2020
Incremental solidification (IS) of small batches of metal powders is a fundamental process in various additive-manufacturing (AM) and 3-D printing (3DP) operations.
Amir Shelef, Eli Jerby
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Crack mitigation in additively manufactured AlCrFe2Ni2 high-entropy alloys through engineering phase transformation pathway

Communications Materials
The far-from-equilibrium solidification during additive manufacturing often creates large residual stresses that induce solid-state cracking. Here we present a strategy to suppress solid-state cracking in an additively manufactured AlCrFe2Ni2 high ...
Shahryar Mooraj, Xizhen Dong, Shengbiao Zhang, Yanming Zhang, Jie Ren, Shuai Guan, Chenyang Li, Rameshwari Naorem, Nicolas Argibay, Wei Chen, Wentao Yan, Dierk Raabe, Zhongji Sun, Wen Chen   +13 more
doaj   +1 more source