Results 71 to 80 of about 19,533,251 (282)

Additive Manufacturing Research and Applications

, 2022
Additive Manufacturing (AM) has undergone somewhat of a revolution over the last decade and it has now evolved into a viable industrial manufacturing solution, able to create complex geometries which are unachievable with traditional manufacturing ...
Atila Ertas, Adam Stroud
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Recent Advances and Future Perspectives in Friction Stir Welding and Processing: A Review

Journal of Manufacturing and Materials Processing
Friction stir welding (FSW) began as a fairly specialized joining method, but over the past three decades it has evolved into something considerably more versatile, a manufacturing platform that now handles complex multi-material assemblies and solid ...
Dan Cătălin Bîrsan, Florin Susac
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Experimental Investigation of the Influence of Wire Arc Additive Manufacturing on the Machinability of Titanium Parts [PDF]

, 2019
Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.The manufacturing of titanium airframe parts involves significant machining and low buy-to-fly ratios.
Veiga, Fernando, Fernando Veiga, Suárez, Alfredo, Teresa Artaza, Alonso, Unai, Unai Alonso, Artaza, Teresa, Alfredo Suárez   +7 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Enhancement of Microstructure, Tensile and Fatigue Performance of EN AW-1050 by Wire-Based Friction Stir Additive Manufacturing

Journal of Manufacturing and Materials Processing
Additive manufacturing (AM) of aluminium by solid-state routes offers a promising pathway to overcome the limitations of fusion-based processes, such as porosity and hot cracking. This study investigates the potential of wire-based friction stir additive
Stefan Donaubauer, Raphael Schmid, Stefan Weihe, Martin Werz   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Solid-State Additive Manufacturing: An Innovative Framework For Sustainable Supply Chain Transformation And Circular Economy

Proceedings of the Conference on Production Systems and Logistics
As recent regional conflicts and the Covid pandemic have shown, global supply chain disruptions can destabilize even the most developed economies. Added to this is the ever-growing need for comprehensive closed-loop, multi-life cycle based sustainable ...
Caudill, James, Badurdeen, Fazleena, Jawahir, I.S.   +2 more
doaj   +1 more source