Results 71 to 80 of about 30,863 (299)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exploring the mechanical performance and material structures of integrated electrical circuits within solid state metal additive manufacturing matrices [PDF]

, 2014
Ultrasonic Additive Manufacturing (UAM) enables the integration of a wide variety of components into solid metal matrices due to a high degree of metal plastic flow at low matrix bulk temperatures.
Alkaios Bournias-Varotsis (1254126), Bournias-Varotsis, A., Russell Harris (1250157), Harris, R. A., Simona Masurtschak (7204403), Ji Li (1259010), Monaghan, T., Harris, R.A., Masurtschak, S., Tom Monaghan (1258749), Li, J., Ross Friel (1248393), Friel, R.J., Friel, R. J.   +13 more
core  

Modeling and simulation of microstructures in metal additive manufacturing

, 2023
In recent years, metal additive manufacturing (AM) has receivedincreasing interest in the field of manufacturing engineeringbecause of its attractive features compared with those ofconventional manufacturing methods.
Kumara, Chamara,
core  

Design approach for additive manufacturing employing Constructal Theory for point-to-circle flows

, 2022
S.111-118Design is crucial for additive manufacturing (AM). Not only does it affect manufacturability and cost but more importantly does it determine the functional performance of a part.
Reinhart, G., Biedermann, M., Kamps, T., Seidel, C.   +3 more
core   +1 more source

Recent developments in additive friction stir deposition (AFSD)

Journal of Materials Research and Technology
In recent years, metal additive manufacturing (MAM) has emerged as a promising technique for faster and easier manufacturing of complex parts. One method developed in MAM is additive friction stir deposition (AFSD), which is based on the friction stir ...
Melike Korgancı, Yahya Bozkurt
doaj   +1 more source

Cold spray - a solid-state additive manufacturing technology

IOP Conference Series: Materials Science and Engineering
Abstract Cold spray is a solid-state powder deposition technique and has evolved into an additive manufacturing process. Unlike conventional additive manufacturing technologies that rely on melting and solidification, cold spray additive manufacturing (CSAM) forms components at low temperatures at a relatively high build rate.
Congcong Su, Yan Wang, Hanqing Che, Stephen Yue, Xiaoxu Huang   +4 more
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Additive manufacturing of fibrous sound absorbers

, 2021
This article is available in SOAR. Click on the DOI to access the publisher’s version (may not be free)We investigate the possibility of additively manufacturing fibrous sound absorbers using fused deposition modeling.
Bhisham Sharma, Johnston, William, Sharma, Bhisham N., William Johnston   +3 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

An overview of functionally graded additive manufacturing [PDF]

, 2018
Functionally Graded Additive Manufacturing (FGAM) is a layer-by-layer fabrication process that involves gradationally varying the material organisation within a component to achieve an intended function.
David Harrison, Mario D. Monzón, Eujin Pei, Pei, Eujin, Loh, GH, Giselle Hsiang Loh, Harrison, David, Monzón, MD, Pei, E, Harrison, D, Loh, Giselle Hsiang, Monzón Verona, Mario D.   +11 more
core   +1 more source