Results 71 to 80 of about 20,335,239 (286)

Additive Manufacturing of Metallic Materials: Structures, Properties and Methodologies

, 2023
Additive manufacturing (AM) is a crucial aspect of contemporary science and engineering, enabling the layer-by-layer production of components [...
Qingsong Wei, Changjun Han, Nataliya Kazantseva   +2 more
core   +1 more source

Recent developments in additive friction stir deposition (AFSD)

Journal of Materials Research and Technology
In recent years, metal additive manufacturing (MAM) has emerged as a promising technique for faster and easier manufacturing of complex parts. One method developed in MAM is additive friction stir deposition (AFSD), which is based on the friction stir ...
Melike Korgancı, Yahya Bozkurt
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Recent Advances and Future Perspectives in Friction Stir Welding and Processing: A Review

Journal of Manufacturing and Materials Processing
Friction stir welding (FSW) began as a fairly specialized joining method, but over the past three decades it has evolved into something considerably more versatile, a manufacturing platform that now handles complex multi-material assemblies and solid ...
Dan Cătălin Bîrsan, Florin Susac
doaj   +1 more source

Cold spray - a solid-state additive manufacturing technology

IOP Conference Series: Materials Science and Engineering
Abstract Cold spray is a solid-state powder deposition technique and has evolved into an additive manufacturing process. Unlike conventional additive manufacturing technologies that rely on melting and solidification, cold spray additive manufacturing (CSAM) forms components at low temperatures at a relatively high build rate.
Congcong Su, Yan Wang, Hanqing Che, Stephen Yue, Xiaoxu Huang   +4 more
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Machine learning in additive manufacturing: State-of-the-art and perspectives

, 2020
Additive manufacturing (AM) has emerged as a disruptive digital manufacturing technology. However, its broad adoption in industry is still hindered by high entry barriers of design for additive manufacturing (DfAM), limited materials library, various ...
Lim, C.S., C.S. Lim, Tan, Xipeng, C. Wang, X.P. Tan, S.B. Tor, Tor, Shu Beng, Wang, Chengcheng   +7 more
core   +1 more source

Design for wire and arc additive layer manufacture [PDF]

, 2010
Additive Layer Manufacture (ALM) is a technique whereby freeform structures are produced by building up material in layers. RUAM (Ready-to-Use Additive Layer Manufacturing) is an innovative concept for building large scale metal ready-to- use parts ...
H. Lockett, P. Kazanas, Lockett, H., Mehnen, J., Ding, J., J. Ding, Lockett, Helen L., J. Mehnen, Mehnen, Jorn, Kazanas, P., Ding, Jialuo   +10 more
core   +1 more source