Results 81 to 90 of about 19,533,251 (282)

Functionally graded additive manufacturing

, 2021
Functionally graded additive manufacturing (FGAM) is a layer-by-layer manufacturing technique that allows material composition and organization to be achieved within a single volume to enable variational functionalities.
Godec, Damir, Nordin, Axel, University, Brunel, Gonzalez-Gutierrez, Joamin, Godec, Damir,, Gonzalez-Gutierrez, Joamin,, Nordin, Axel,, University, Brunel,, Pei, Eujin, Pei, Eujin,, Lund University.   +10 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Current application status and prospects of machine learning in friction stir welding and additive manufacturing

Cailiao gongcheng
Friction stir welding and its derived solid-state additive manufacturing technologies stand as one of the effective approaches to avoid melting defects and achieve the fabrication of high-performance lightweight alloy components.
SHI Lei, DAI Guoxin, ZHANG Xiankun, WU Chuansong, YAN Shitao   +4 more
doaj   +1 more source

Novel Technique for Design and Manufacture of Alternating Gradient Composite Structure of Aluminum Alloys Using Solid State Additive Manufacturing Technique. [PDF]

Materials (Basel), 2022
Venkit H, Selvaraj SK.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Wire-based friction stir additive manufacturing towards isotropic high-strength-ductility Al-Mg alloys

Virtual and Physical Prototyping
The formation of eutectic Al-Mg2Al3 phases along the grain boundaries makes it difficult to improve the mechanical properties of high-magnesium-content aluminum alloys. Here, wire-based friction stir additive manufacturing(W-FSAM) was proposed as a novel
Jinqi Wang, Yuming Xie, Xiangchen Meng, Yaobang Zhao, Shuming Sun, Junchen Li, Jialin Chen, Huizi Chen, Xiaotian Ma, Naijie Wang, Yongxian Huang   +10 more
doaj   +1 more source

Additive manufacturing of Inconel 718 using solid-state bonding

, 2022
The capability for manufacturing large-scale metallic components is a sign of a country's productive capacity. Further capability improvement is limited by factors such as quality control during the casting (solidification defects), the high tonnage requirement on equipment and the high energy consumption of the processes.
openaire   +2 more sources

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Design for wire and arc additive layer manufacture [PDF]

, 2010
Additive Layer Manufacture (ALM) is a technique whereby freeform structures are produced by building up material in layers. RUAM (Ready-to-Use Additive Layer Manufacturing) is an innovative concept for building large scale metal ready-to- use parts ...
H. Lockett, P. Kazanas, Lockett, H., Mehnen, J., Ding, J., J. Ding, Lockett, Helen L., J. Mehnen, Mehnen, Jorn, Kazanas, P., Ding, Jialuo   +10 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source