Results 41 to 50 of about 275,187 (297)

Diode-pumped solid state laser light sources for confocal laser scanning fluorescence microscopy

, 2008
Diode-pumped solid-state lasers (DPSSLs) have been integrated as light sources in confocal laser scanning microscopy (CLSM). The standard argon ion laser at 488 rim is compared with a DPSSL operating at 473 run in terms of noise and CLSM image ...
Stjernström, Mårten,, Brismar, Hjalmar, Hjalmar Brismar, Mårten Stjernström, Laurell, F, Brismar, H,, Fredrik Laurell, Laurell, Fredrik,, Stjernstrom, M   +8 more
core   +1 more source

Solid immersion lens applications for nanophotonic devices [PDF]

, 2008
Solid immersion lens (SIL) microscopy combines the advantages of conventional microscopy with those of near-field techniques, and is being increasingly adopted across a diverse range of technologies and applications. A comprehensive overview of the state-
O'Connor, John A., Reid, Derryck T.; id_orcid, Serrels, Keith A., Dalgarno, P.A., Ramsay, E., Reid, D.T., Warburton, R.J., Hadfield, R.H., Warburton, Richard J., Ramsay, Euan, Hadfield, Robert H., Gerardot, B., Serrels, K.A., Dalgarno, Paul A.; id_orcid, O'Connor, J., Gerardot, Brian D.   +15 more
core   +1 more source

Circular output from a high power Nd:YLF slab laser

, 2008
Neodymium-doped Yttrium Lithium Fluoride (YLF) lasers have traditionally been power-limited by the relatively low tensile strength of the crystal. When power-scaling solid-state lasers, the choice of the gain media geometry, the doping level, and the ...
J. I. Mackenzie, Clarkson, W.A., W. A. Clarkson, Mackenzie, J.I.   +3 more
core   +1 more source

Study on the Internal Mechanism of APD Photocurrent Characteristics Caused by the ms Pulsed Infrared Laser Irradiation

Crystals, 2021
In this paper, the sampling current characteristics of the external circuit and the internal mechanism of the current generation in APD irradiated by a millisecond pulse laser were studied.
Liang Chen, Di Wang, Guang-Yong Jin, Zhi Wei   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Multi-mJ SWIR OPCPA pumped and seeded with 1.2 ps Yb:YAG laser [PDF]

EPJ Web of Conferences, 2022
Petrulėnas Augustinas, Butkutė Aistė, Mackonis Paulius, Rodin Aleksej M.   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Fiber-coupled high brightness high power diode laser for solid-state laser pumping and material processing

, 2022
S.47-53Two applications emerge as drivers for higher brightness fiber-coupled diode lasers: advanced solid-state pumping schemes and materials processing.
Ehlers, B., Heinemann, S., Doerfel, F.
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source