Results 61 to 70 of about 30,101 (306)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
DESIGN AND OPERATION OF A SOLID-STATE TRANSFORMER FOR INTEGRATION OF RENEWABLE ENERGY SYSTEMS
Taikomieji tyrimai studijose ir praktikoje, 2020 Renewable energy-based grid integrations in distribution systems cause changes in the energy structure of the grid such as load flow, short circuit and protection coordination.
Burak Esenboğa +2 more
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Remarks on solid state amorphizing transformations [PDF]
Journal of the Less Common Metals, 1988 Abstract Amorphous solids can now be produced through a variety of laboratory synthesis techniques as well as through many naturally occurring processes. In general, we might classify the methods of synthesis of amorphous solids as follows: (a) rapid solidification of melts or vapors; (b) atomic disordering of crystalline lattices; (c) solid state ...
Schwarz, R. B., Johnson, W. L.
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Modeling and Stability Analysis of a Smart Transformer-Fed Grid
IEEE Access, 2020 The interaction of the smart transformer (ST) with the grid-converter-based distributed energy resources (DERs) could trigger instability. Recent research efforts have been made to study the stability issues caused by the resonances (e.g.
Zhixiang Zou +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
IEEE Access, 2020 Solid-state transformer (SST) is an emerging technology integrating with a transformer power electronics converters and control circuitry. This paper comprehensively reviews the SST topologies suitable for different voltage levels and with varied stages,
Mahammad A. Hannan +6 more
doaj +1 more source
Solid insulation distribution transformer
, 2021 The SIDT (solid insulation distribution transformer) was developed to provide an alternative solution to replace liquid-filled transformers that might leak oil to contaminate surrounding soil and underground water.
Mun, Byungchul +2 more
core +1 more source