Results 41 to 50 of about 9,003 (260)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

4.5 kW High Frequency Transformer Design for Dual Active Bridge (DAB)

Jurnal Elkomika
ABSTRAK Indonesia bertujuan untuk beralih dari bahan bakar fosil ke sumber energi terbarukan, dengan target integrasi sebesar 23% pada tahun 2025 dan 31% pada tahun 2050.
NAUFAL HILMI FAUZAN, EKA FIRMANSYAH, FELIX AUSTIN CAHYADEWA   +2 more
doaj   +1 more source

Copper Pipes as Medium Frequency Transformer Windings

IEEE Access, 2022
Owing to increasing power demand, new technologies, such as solid-state transformers, are progressively researched and improved. Thereby, galvanic isolation and voltage adaptation are achieved by medium frequency transformers. To reach high power density
Nikolina Djekanovic, Drazen Dujic
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Comparison of Isolated DC-DC Converters for Low/Medium Voltage Solid State Transformer applications [PDF]

Journal of Electrical and Electronics Engineering, 2022
This paper presents a comparative evaluation of isolated dc-dc converter topologies used in Solid State Transformers (SST) meant for low/medium voltage standalone applications.
R B Jeyapradha, V Rajini
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Isolation Transformer for 3-Port 3-Phase Dual-Active Bridge Converters in Medium Voltage Level

IEEE Access, 2019
In this paper, an isolation transformer with integrated filter inductances for three-phase three-port dual-active bridge (DAB) converters in the wye-wye-delta (Yyd) configuration is introduced and designed.
Seunghun Baek, Subhashish Bhattacharya
doaj   +1 more source

Solid State Transformer with Integrated Input Stage

2019 IEEE International Conference on Industrial Technology (ICIT), 2019
In this paper, a solid state transformer (SST) with integrated stages is addressed. The SST has been originally proposed for traction applications, after as an option to face the new requirements of the distributed generation but also suggested in many applications. There are different topologies, from one to three stages; certainly each one with their
Nimrod Vázquez, Marco Liserre
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source