Results 71 to 80 of about 19,472,085 (300)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

DESIGN AND OPERATION OF A SOLID-STATE TRANSFORMER FOR INTEGRATION OF RENEWABLE ENERGY SYSTEMS

open access: yesTaikomieji tyrimai studijose ir praktikoje, 2020
Renewable energy-based grid integrations in distribution systems cause changes in the energy structure of the grid such as load flow, short circuit and protection coordination.
Burak Esenboğa   +2 more
doaj  

Modeling and Stability Analysis of a Smart Transformer-Fed Grid

open access: yesIEEE Access, 2020
The interaction of the smart transformer (ST) with the grid-converter-based distributed energy resources (DERs) could trigger instability. Recent research efforts have been made to study the stability issues caused by the resonances (e.g.
Zhixiang Zou   +3 more
doaj   +1 more source

Mechanochemically Induced Solid-State Transformations of Levofloxacin

open access: yesMolecular Pharmaceutics
Levofloxacin hemihydrate (LVXh) is a complex fluoroquinolone drug that exists in both hydrated and anhydrous/dehydrated forms. Due to the complexity of such a compound, the primary aim of this study was to investigate the amorphization capabilities and solid-state transformations of LVXh when exposed to mechanical treatment using ball milling.
Lena Kadri   +4 more
openaire   +3 more sources

Solid state phase detector replaces bulky transformer circuit [PDF]

open access: yes, 1967
Miniature solid state phase detector using MOSFETs is used in a phase lock loop with a sun-bit detector in an integrated data-link circuit. This replaces bulky transformer circuits.
Moberly, C. L.
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

State of the Art of Solid-State Transformers: Advanced Topologies, Implementation Issues, Recent Progress and Improvements

open access: yesIEEE Access, 2020
Solid-state transformer (SST) is an emerging technology integrating with a transformer power electronics converters and control circuitry. This paper comprehensively reviews the SST topologies suitable for different voltage levels and with varied stages,
Mahammad A. Hannan   +6 more
doaj   +1 more source

Solid-State Transformer (S2T) of Single Phase Matrix Converter [PDF]

open access: yes, 2018
Solid-State Transformer (S2T) also known as Power Electronic Transformer (PET) is applied in various industrial fields compared to the conventional transformer due to it flexible voltage transfer ratio, high power density, and low harmonic distortion ...
Baharom, Rahimi   +3 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

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