Results 51 to 60 of about 19,142,771 (202)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Isolation Transformer for 3-Port 3-Phase Dual-Active Bridge Converters in Medium Voltage Level

open access: yesIEEE Access, 2019
In this paper, an isolation transformer with integrated filter inductances for three-phase three-port dual-active bridge (DAB) converters in the wye-wye-delta (Yyd) configuration is introduced and designed.
Seunghun Baek, Subhashish Bhattacharya
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

State of the Art of Solid-State Transformers: Advanced Topologies, Implementation Issues, Recent Progress and Improvements

open access: yesIEEE Access, 2020
Solid-state transformer (SST) is an emerging technology integrating with a transformer power electronics converters and control circuitry. This paper comprehensively reviews the SST topologies suitable for different voltage levels and with varied stages,
Mahammad A. Hannan   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

DESIGN AND OPERATION OF A SOLID-STATE TRANSFORMER FOR INTEGRATION OF RENEWABLE ENERGY SYSTEMS

open access: yesTaikomieji tyrimai studijose ir praktikoje, 2020
Renewable energy-based grid integrations in distribution systems cause changes in the energy structure of the grid such as load flow, short circuit and protection coordination.
Burak Esenboğa   +2 more
doaj  

Solid state phase detector replaces bulky transformer circuit [PDF]

open access: yes, 1967
Miniature solid state phase detector using MOSFETs is used in a phase lock loop with a sun-bit detector in an integrated data-link circuit. This replaces bulky transformer circuits.
Moberly, C. L.
core  

Solid-State Transformer (S2T) of Single Phase Matrix Converter [PDF]

open access: yes, 2018
Solid-State Transformer (S2T) also known as Power Electronic Transformer (PET) is applied in various industrial fields compared to the conventional transformer due to it flexible voltage transfer ratio, high power density, and low harmonic distortion ...
Baharom, Rahimi   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy