Results 31 to 40 of about 11,987,372 (291)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The technological impact of diffusion in nanopores [PDF]

, 2005
The impact of nanopore diffusion on the performance of adsorption separation processes is reviewed. Zeolite membrane processes and kinetically selective cyclic adsorption processes depend for their selectivity on differences in intracrystalline diffusion
Ruthven, Douglas M.
core   +1 more source

Multistage-optimized kinetics-diffusion modeling for solid-liquid denitrification: From predictive control to model validation

Energetic Materials Frontiers
To analyze the effects of temperature, concentration, and reaction time on the denitration rate of double based spherical gun propellant (DBSGP) and to investigate the denitration reaction-diffusion coupling process for achieving precise denitration rate
Chen-zhao Gao, Yu-nong Liu, Qi Yang, Hong-wei Zhou, Ya-jun Ding, Shi-ying Li   +5 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Control of secondary flow in a low solidity circular cascade diffuser

Journal of Thermal Science, 2012
According to the previous experimental works on the low solidity circular cascade diffuser (LSD), a pressure recovery of a centrifugal blower was improved by the LSD significantly in a wide range of flow rate, and the pressure recovery was improved further by the LSD with a tandem cascade in comparison with the LSD with a single- row cascade.
Daisaku Sakaguchi, Takuji Fujii, Hironobu Ueki, Masahiro Ishida, Hiroshi Hayami   +4 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Investigations of solid liquid interfaces in ultra-thin liquid films via single particle tracking of silica particles [PDF]

, 2009
Single particle tracking with a wide field microscope is used to study the solid liquid interface between the viscous liquid tetrakis(2 ethylhexoxy)-silane and a silicon dioxide surface.
Bok, Sangho, Trenkmann, Ines, Borczyskowski, Christian von, Gangopadhyay, Shubhra, Täuber, Daniela, Bauer, Michael, Schuster, Jörg   +6 more
core   +1 more source

Sterically protected π-electron systems for efficient solid-state photon upconversion

Nature Communications
A solid-state visible-to-ultraviolet triplet–triplet annihilation-based photon upconversion system driven by low-intensity light at sunlight levels is developed.
Naoyuki Harada, Hayato Shoyama, Nutnicha Boonmong, Kiichi Mizukami, Yuya Watanabe, Pei Zhao, Masahiro Ehara, Yoichi Sasaki, Nobuo Kimizuka   +8 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source