Results 31 to 40 of about 197,986 (311)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Potentiality of caro’s acid in leaching of uranium from Abu-Rusheid mylonitic gneiss rocks, South Eastern Desert, Egypt

Results in Materials, 2021
Abu Rusheid area is located at the Southern Eastern Desert of Egypt and composed of Mylonitic gneiss rocks (mineralized rock), Serpentinite rocks, Ophiolitic metagabbro, Ophiolitic mélange, Monzogranites, post-granitic dykes (lamprophyre and dolerite ...
Mohamed S. Nagar, Walid M. Morsy, Mostafa. B Bayoumi, Ahamed S. Shalan   +3 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Multistage-optimized kinetics-diffusion modeling for solid-liquid denitrification: From predictive control to model validation

Energetic Materials Frontiers
To analyze the effects of temperature, concentration, and reaction time on the denitration rate of double based spherical gun propellant (DBSGP) and to investigate the denitration reaction-diffusion coupling process for achieving precise denitration rate
Chen-zhao Gao, Yu-nong Liu, Qi Yang, Hong-wei Zhou, Ya-jun Ding, Shi-ying Li   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Solid-State Divalent Ion Conduction in ZnPS₃

, 2019
Next-generation batteries based on divalent working ions have the potential to both reduce the cost of energy storage devices and increase performance.
Kimberly A. See, Andrew J. Martinolich (1630642), Cheng-Wei Lee (2332780), André Schleife (1511032), I-Te Lu, André Schleife, I-Te Lu (6469340), Molleigh B. Preefer (5593109), Sarah C. Bevilacqua, Kimberly A. See (1774297), Cheng-Wei Lee, Molleigh B. Preefer, Sarah C. Bevilacqua (6469343), Marco Bernardi (1674757), Andrew J. Martinolich, Marco Bernardi   +15 more
core   +1 more source

Peculiarities of the diffusion zone formation of the platinum-titanium compound

Авіаційно-космічна техніка та технологія, 2022
This paper considers the possibility of obtaining a high-quality titanium-platinum compound. Difficulties in joining dissimilar metals lie in the fact that during their interaction, brittle intermetallic compounds are formed, which cause the destruction ...
Anatoliy Sanin, Igor Mamchur, Yevhen Dzhur, Stella Mamchur, Tetjana Nosova   +4 more
doaj   +1 more source

Control of secondary flow in a low solidity circular cascade diffuser

Journal of Thermal Science, 2012
According to the previous experimental works on the low solidity circular cascade diffuser (LSD), a pressure recovery of a centrifugal blower was improved by the LSD significantly in a wide range of flow rate, and the pressure recovery was improved further by the LSD with a tandem cascade in comparison with the LSD with a single-row cascade.
Daisaku Sakaguchi, Takuji Fujii, Hironobu Ueki, Masahiro Ishida, Hiroshi Hayami   +4 more
openaire   +1 more source