Results 101 to 110 of about 56,129 (292)

Green Solid Lipid Nanoparticles by Fatty Acid Coacervation: An Innovative Nasal Delivery Tool for Drugs Targeting Cerebrovascular and Neurological Diseases

Pharmaceutics
Cerebrovascular and neurological diseases are characterized by neuroinflammation, which alters the neurovascular unit, whose interaction with the choroid plexus is critical for maintaining brain homeostasis and producing cerebrospinal fluid. Dysfunctions
Annalisa Bozza, Valentina Bordano, Arianna Marengo, Elisabetta Muntoni, Elisabetta Marini, Loretta Lazzarato, Chiara Dianzani, Chiara Monge, Arianna Carolina Rosa, Luigi Cangemi, Maria Carmen Valsania, Barbara Colitti, Ezio Camisassa, Luigi Battaglia   +13 more
doaj   +1 more source

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

Beilstein Journal of Nanotechnology, 2019
This investigation is a study of new lipid nanoparticles for cutaneous antioxidant delivery. Several molecules, such as α-tocopherol and retinoic acid, have been shown to improve skin condition and even counteract the effects of exogenous stress factors ...
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Giuseppe Valacchi, Rita Cortesi   +7 more
doaj   +1 more source

Solid Lipid Nanoparticle: A Review

IOSR Journal of Pharmacy (IOSRPHR), 2012
– Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in othervaried sciences. Solid lipid nanoparticle (SLN) dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous ...
openaire   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study

, 2018
Noha M Badawi,1 Mahmoud H Teaima,2 Khalid M El-Say,3 Dalia A Attia,1 Mohamed A El-Nabarawi,2 Mohey M Elmazar4 1Department of Pharmaceutics, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt; 2Department of Pharmaceutics and ...
Attia DA, Elmazar MM, El-Nabarawi MA, El-Say KM, Badawi NM, Teaima MH   +5 more
core  

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy

, 2018
Marc Suñé-Pou,1–3 Silvia Prieto-Sánchez,2 Younes El Yousfi,2 Sofía Boyero-Corral,2 Anna Nardi-Ricart,1 Isaac Nofrerias-Roig,1 Pilar Pérez-Lozano,1,3 Encarna García-Montoya,1,3 Montserrat Miñarro ...
Hernández-Munain C, Pérez-Lozano P, Miñarro-Carmona M, Nofrerias-Roig I, Suñé-Pou M, Suñé-Negre JM, Boyero-Corral S, Ticó JR, El Yousfi Y, Prieto-Sánchez S, Nardi-Ricart A, Suñé C, García-Montoya E   +12 more
core  

Nanocarreadores lipídicos contendo quercetina: desenvolvimento, caracterização físico-química e avaliação biológica in vivo [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010A quercetina (QU) é um polifenol pertencente à classe dos flavonóides, presente na dieta humana.
Dora, Cristiana Lima
core  

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source