Results 61 to 70 of about 114,436 (357)

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

A Correlative Imaging Study of in vivo and ex vivo Biodistribution of Solid Lipid Nanoparticles

International Journal of Nanomedicine, 2020
Silvia Mannucci,1 Federico Boschi,2,* Barbara Cisterna,1,* Elisabetta Esposito,3 Rita Cortesi,3 Claudio Nastruzzi,3 Enrica Cappellozza,1 Paolo Bernardi,1 Andrea Sbarbati,1 Manuela Malatesta,1 Laura Calderan1 1Department of Neurosciences, Biomedicine and ...
Mannucci S, Boschi F, Cisterna B, Esposito E, Cortesi R, Nastruzzi C, Cappellozza E, Bernardi P, Sbarbati A, Malatesta M, Calderan L   +10 more
doaj  

Lipid Nanoparticles for Drug Delivery

Advanced NanoBiomed Research, 2022
Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995.
Letao Xu, Xing Wang, Yun Liu, Guangze Yang, Robert J. Falconer, Chun-Xia Zhao   +5 more
doaj   +1 more source

Lysosomal tracking with red-fluorescent solid lipid nanoparticles

OpenNano, 2022
Lysosomes are organelles with many functions in cell metabolism, the morphology changes as a function of the different cellular mechanisms. Some enzymes in the lysosomal medium are responsible for the cellular digestion process.
Hellen Franciane Gonçalves Barbosa, Henrique Luis Piva, Antonio Claudio Tedesco   +2 more
doaj   +1 more source

Structural properties and Raman spectroscopy of lipid Langmuir monolayers at the air-water interface

, 2010
Spectra of octadecylamine (ODA) Langmuir monolayers and egg phosphatidylcholine (PC)/ODA-mixed monolayers at the air-water interface have been acquired.
Aroca., Bohdana, Chamberlain, Chazalet, Curtis, Fendler, Frank, Greenhall, Guo, Hill, Hongxin Dang, Honig, Huang, Ignes-mullol, Kobayashi, Lee, Lin, Lin-Vien, Maquelin, Marg, Meldrum, Michota, Moskovits, Nie, Patil, Peter, Pettinger, Rivas, Roberts, Samned, Schoefisch, Shuxi Dai, Song, Spiker, Taylor, Thompson, Tollner, Tsen, Wong, Xingtang Zhang, Yabin Huang, Young, Zuliang Du   +42 more
core   +1 more source

Nanoparticles-cell association predicted by protein corona fingerprints [PDF]

, 2016
In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes ...
Caracciolo, Giulio, Digiacomo, L., Mahmoudi, M., Micarelli, E., Palchetti, S., Peruzzi, G., Pozzi, Daniela   +6 more
core   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

Ternary nanoparticles composed of cationic solid lipid nanoparticles, protamine, and DNA for gene delivery

International Journal of Nanomedicine, 2013
Sai-Nan He,1 Yun-Long Li,1,2 Jing-Jing Yan,2 Wei Zhang,2 Yong-Zhong Du,2 He-Yong Yu,1 Fu-Qiang Hu,2 Hong Yuan21Women’s Hospital, 2College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ...
He SN, Li YL, Yan JJ, Zhang W, Du YZ, Yu HY, Hu FQ ,Yuan H   +6 more
doaj  

Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes : towards a vaginal sustained released system for siRNA [PDF]

, 2016
peer reviewedTopical vaginal sustained delivery of siRNA presents a significant challenge due to the short residence time of formulations. Therefore, a drug delivery system capable to adhere to the vaginal mucosa is desirable, as it could allow a ...
Furst, Tania, Dakwar, George, Zagato, Elisa, Lechanteur, Anna, Remaut, Katrien, Evrard, Brigitte, Braeckmans, Kevin, Piel, Geraldine   +7 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source