Results 61 to 70 of about 5,601,796 (250)

Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation Using CT imaging

Pharmaceutics, 2020
Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal imaging during pre-clinical studies
Noemí Gómez-Lado, Iria Seoane-Viaño, Silvia Matiz, Christine M. Madla, Vipul Yadav, Pablo Aguiar, Abdul W. Basit, Alvaro Goyanes   +7 more
doaj   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Oral Solid Dosage Forms

Oral drug delivery remains the most popular and convenient way of administering drugs in comparison with the other routes. Advantages include their effectiveness, convenience, less expensive, and non-invasiveness.
Muhamad, Haja, Asare-Addo, Kofi, Totea, Ana‑Maria, Rowland, Martin, Adebisi, Adeola; id_orcid   +4 more
core   +1 more source

Caracterização e estudos das propriedades no estado sólido do cloridrato de venlafaxina [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.O cloridrato de venlafaxina (VEN) é um inibidor da recaptação da serotonina e norepinefrina eficaz no ...
Bernardi, Larissa Sakis
core  

3D printing of lipid-based formulations into personalized solid oral dosage forms [Elektronisk resurs]

, 2023
The pharmaceutical development process starts with patient populations and their unmet therapeutic needs. Traditional pharmaceutical manufacturing of solid oral dosage forms is based on the strategy of one-size-fits-all.
Paulsson, Mattias,, Johannesson, Jenny,, Bergström, Christel,, Teleki, Alexandra,, Strömme, Maria,, Basit, Abdul,   +5 more
core  

Biowaiver monographs for immediate release solid oral dosage forms: Aciclovir [PDF]

, 2008
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing (biowaiver) for the approval of immediate release (IR) solid oral dosage forms containing aciclovir are reviewed.
Arnal, J., Bermejo, M., Barends, D. M., Midha, Kamal K., Shah, V. P., Dressman, Jennifer B., Junginger, H. E., Amidon, Gordon L., Stavchansky, S., Kopp, S., Gonzalez-Alvarez, I.   +10 more
core   +1 more source

Suitability of the z-Factor for Dissolution Simulation of Solid Oral Dosage Forms

, 2022
S.2735-2745Parameterization of dissolution profiles for subsequent use in in silico modeling and simulation is a crucial element for the success of extrapolating in vitro to in vivo release from solid oral dosage forms.
Hofsäss, M.A., Dressman, J.
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

The potential of three-dimensional printing for pediatric oral solid dosage forms

Acta Pharmaceutica
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid ...
Kreft Klemen, Fanous Marina, Möckel Volker   +2 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source