Results 121 to 130 of about 1,339 (211)

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

Bipolar Palladium Membrane Enabling Crossover‐Free Selective Proton Transport

Advanced Science, EarlyView.
This study introduces a crossover‐free bipolar palladium membrane that transports protons selectively via reversible Pd/PdHx absorption–desorption and lattice hydrogen diffusion, overcoming the conductivity–selectivity trade‐off of polymer membranes. It enables water‐fed Li‐mediated ammonia synthesis, achieving 51% Faradaic efficiency and stable 12 h ...
Jiyeon Baek, Yeongbae Jeon, Seunga Lee, Ahee Choi, Joonmok Shim, Kyungho Lee, Ho Woun Jung, Sun Hyung Kim, Churl Hee Cho, Hyung Chul Yoon, Yun Jeong Hwang, Jae Hyung Kim   +11 more
wiley   +1 more source

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Overcoming the Catalytic Bucket Effect in Pt‐based High‐Entropy Nanocages Through Interface Defect and Strain Engineering

Advanced Science, EarlyView.
PtPdNiCuMnAu HENCs exhibit a remarkable half‐wave potential (E1/2) of 0.925 V vs. RHE. The catalyst displays exceptional electrochemical stability, with only a 4 mV negative shift in E1/2 and a mere 5.6% loss in MA after 10, 000 accelerated durability test cycles.
Qian Liu, Haoran Kang, Yiou Liu, Xiaowei Zhang, Xu Chen, Faming Gao   +5 more
wiley   +1 more source

Continuous‐Flow Microfluidic Synthesis Enhances C2+ Selectivity for Cu2O Catalysts

Advanced Science, EarlyView.
Microfluidic devices are used to prepare Cu2O nanoparticles under laminar flow conditions, which exhibit enhanced selectivity in the CO2‐to‐C2+ reaction due to their nanoporosity and high defect concentration. Cu2O prepared using standard solution methods displays decreased CO2‐to‐C2+ selectivity due to the absence of similar properties. Altogether, we
Carlota Casas, Anh Tuan Ngo, João Pedro Vale, Ona Falcó, Gerard Martí, Mohamed Amazian, Júlia Mayans, Sònia Estradé, Marcos Gil‐Sepulcre, Teresa Andreu, Francesca Peiró, Tiago Sotto Mayor, Lluís Yedra, Jordi García‐Antón, Josep Puigmartí‐Luis, Xavier Sala, Roc Matheu   +16 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Diastereomeric Monomers Enable Anion‐Exchange Membranes With Controlled Local Polymer Backbone Flexibility and High Conductivity

Advanced Science, EarlyView.
Stereochemistry enables control of ion‐exchange membrane properties via local backbone flexibility without altering the polymer composition. Syn‐enriched membranes show higher water uptake and improved water‐electrolysis performance, whereas anti‐enriched membranes exhibit higher hydration efficiency and improved mechanical properties.
Si Chen, Xuchen Lyu, Triet Nguyen Dai Luong, Patric Jannasch   +3 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

Advanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais, S. Peng, J. Chang, F. Li, Q. Zhu, K. Yuan, G. Hugelius, H. Li, Y. Cai, F. Chevallier, K. Tibrewal, E. A. Kort, K. Arndt, J. Watts, B. Buma, N. Besic, P. I. Palmer, H. Cadillo‐Quiroz, E. Euskirchen, M. J. Gondwe, A. Hoyt, R. Jackson, S. Malone, D. Monteverde, S. Natali, M. Ramonet, C. Rey‐Sanchez, L. B. Sagang, E. A. G. Schuur, R. Vargas, R. Varner, Z. Zhang, B. Poulter   +32 more
wiley   +1 more source