Results 141 to 150 of about 1,860 (260)

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

open access: yesAdvanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang   +11 more
wiley   +1 more source

Multi‐Stimuli Responsive Magneto‐Coacervate Droplets for Selective Molecular Enrichment and Programmable Manipulation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical ...
Kailang Liu   +6 more
wiley   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

open access: yesAdvanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun   +9 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

open access: yesAdvanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu   +11 more
wiley   +1 more source

Nano-Iron as a Catalyst in Isocyanate-Free Rocket Propellants. [PDF]

open access: yesPolymers (Basel)
Chmielarek M   +2 more
europepmc   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

open access: yesAdvanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen   +12 more
wiley   +1 more source

A Bifunctional Organosilane Additive for Dynamic pH Regulation and Interfacial Protection in Aqueous Zinc‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
A novel multifunctional additive for aqueous zinc‐ion battery electrolytes can simultaneously dynamically adjust the pH in microzones, regulate the solvation structure of Zn2+, protect the interface, and form a stable solid‐state SEI film. This approach enables a dendrite‐free zinc anode and demonstrates excellent cycling stability and cycle life ...
Lina Pan   +5 more
wiley   +1 more source

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