Results 131 to 140 of about 4,672,322 (298)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
NMR studies of silicate & aluminosilicate solutions [PDF]
, 2001 The work described in this thesis deals with the use of (^29)Si and (^27)Al NMR to obtain information about the chemical structure of aqueous silicate and aluminosilicate solutions. This has extended the knowledge gained in previous studies. A wide range
Azizi, Seyed Naser
core
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Mathematical models for chemical bonds forming of CdSb–ZnSb solid solutions
Технологія та конструювання в електронній апаратурі, 2009 Mathematical models for the comprehensive studies of the dynamics of formation of chemical bonds of CdxZn1–xSb solid solutions in the whole range concentrations (0≤x≤1) were proposed.
A. A. Ashcheulov +3 more
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
CARATTERIZZAZIONE ELETTRICA E SPETTROSCOPICA AD IMPEDENZA DI OSSIDI METALLICI NANOSTRUTTURATI PER IL RILEVAMENTO DI ALCANI VOLATILI [PDF]
, 2009 Chemoresistive gas sensors using semiconductor metal-oxides have proven to be excellent in important characteristics such as sensitivity, long-term stability, robustness and price. Solid solutions of mixed Sn and Ti oxides have shown promising results in
Cervi, Alan
core