Results 41 to 50 of about 2,740,066 (299)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Sequences space ℓ𝑝 𝑁 of neutrosophic real numbers [PDF]

Songklanakarin Journal of Science and Technology (SJST)
The article reveals concept of ℓ𝑝 𝑁(𝑋), 1 ≤ 𝑝 < ∞, the p – absolutely summable neutrosophic valued sequence space. We have proved that it is a neutrosophic normed linear space valued sequence space.
Arghyadip Debroy, Runu Dhar, Binod Chandra Tripathy   +2 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Progress and perspective of the cathode/electrolyte interface construction in all‐solid‐state lithium batteries

Carbon Energy, 2021
Security risks of flammability and explosion represent major problems with the use of conventional lithium rechargeable batteries using a liquid electrolyte.
Shiming Su, Jiabin Ma, Liang Zhao, Kui Lin, Qidong Li, Shasha Lv, Feiyu Kang, Yan‐Bing He   +7 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Laparoscopic resection of a neuroendocrine tumor that almost fully replaced tailgut cysts: a case report

Surgical Case Reports, 2020
Background Neuroendocrine tumors (NETs) originate from neuroendocrine cells, which are found throughout the body. NETs occur principally in the gastrointestinal tract (approximately 65%) and bronchopulmonary tract (approximately 25%) but rarely occur in ...
Keita Kodera, Seiichiro Eto, Nei Fukasawa, Wataru Kai, Tomo Matsumoto, Tsuyoshi Hirabayashi, Hidejiro Kawahara, Nobuo Omura   +7 more
doaj   +1 more source

Simulating ice-shelf extent using damage mechanics

Journal of Glaciology, 2022
Inaccurate representations of iceberg calving from ice shelves are a large source of uncertainty in mass-loss projections from the Antarctic ice sheet. Here, we address this limitation by implementing and testing a continuum damage-mechanics model in a ...
Samuel B. Kachuck, Morgan Whitcomb, Jeremy N. Bassis, Daniel F. Martin, Stephen F. Price   +4 more
doaj   +1 more source

A simple derivation of level spacing of quasinormal frequencies for a black hole with a deficit solid angle and quintessence-like matter

, 2010
In this paper, we investigate analytically the level space of the imaginary part of quasinormal frequencies for a black hole with a deficit solid angle and quintessence-like matter by the Padmanabhan's method \cite{Padmanabhan}.
A. Vilenkin, B. Ratra, E. Berti, G. Hinshaw, H.P. Nollert, I.S. Gradshteyn, L. Motl, M. Barriola, M. Kowalski, P. Xi, Ping Xi, R.R. Caldwell, S. Ho, T. Padmanabhan, T. Regge, T.R. Choudhury, W.J. Percival, X.Z. Li, X.Z. Li, X.Z. Li, X.Z. Li, X.Z. Li, X.Z. Li, Xi-Chen Ao, Xin-Zhou Li   +24 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Difference sequence space m(M,ø,Ämn,p) F of fuzzy real numbers

Mathematical Modelling and Analysis, 2008
The difference sequence space m(M, ø, Äm n,p) F of fuzzy real numbers for both 1 ≤ p < 8 and 0
Binod Chandra Tripathy, Stuti Borgohain
doaj