Results 71 to 80 of about 19,360,112 (295)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Fabrication technologies for flexible OLED lighting modules

, 2022
Paper SSTh2B.5Flexible OLED allows new kinds of curved and transparent lighting systems. Specific topics of flexible OLED fabrication by sheet-to-sheet and roll-to-roll processing of polymer webs, metal foils and flexible ultra-thin glass the will be ...
May, C.
core   +1 more source

Imagining the future of office lighting: smart, sustainable, solid-state

, 2013
This is a time of revolutionary change in the lighting industry. Solid-state lighting (SSL) systems are on track to achieve lighting efficiencies for general lighting in excess of 150 lumens per watt (lm/W) in the not-too-distant future (see http://www1 ...
Dikel, E. Erhan, Veitch, Jennifer A.
core   +1 more source

High-resistive layers obtained through periodic growth and in situ annealing of InGaN by metalorganic chemical vapor deposition

AIP Advances, 2016
High-resistive layers were obtained by periodic growth and in situ annealing of InGaN. The effect of the annealing temperature of InGaN on the indium content and the material sheet resistive was investigated.
Shuo Zhang, Ping Ma, Boting Liu, Dongxue Wu, Yuliang Huang, Junxi Wang, Jinmin Li   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Energy Conversion: Solid-State Lighting

, 2013
This chapter discusses recent developments in first-principles computational methods for the study of nitride materials employed for solid-state lighting.
Kioupakis, E., A. Janotti, P. Rinke, Q. Yan, Yan, Q., Janotti, A., C.G. Van de Walle, Van de Walle, C., E. Kioupakis, Rinke, P.   +9 more
core   +1 more source

Effect of Carrier Localization and Shockley-Read-Hall Recombination on the Spatial Distribution of Electroluminescence in InGaN LEDs

IEEE Photonics Journal, 2018
We investigate divergent behaviors in the emission of blue and green light-emitting diodes (LEDs) when they are subjected to the current-stress aging.
Zhangbao Peng, Yijun Lu, Yulin Gao, Guolong Chen, Jianfei Zheng, Ziquan Guo, Yue Lin, Zhong Chen   +7 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Self-polarized RGB device realized by semipolar micro-LEDs and perovskite-in-polymer films for backlight applications

Opto-Electronic Advances
In backlighting systems for liquid crystal displays, conventional red, green, and blue (RGB) light sources that lack polarization properties can result in a significant optical loss of up to 50% when passing through a polarizer.
Tingwei Lu, Yue Lin, Tianqi Zhang, Yue Huang, Xiaotong Fan, Shouqiang Lai, Yijun Lu, Hao-Chung Kuo, Zhong Chen, Tingzhu Wu, Rong Zhang   +10 more
doaj   +1 more source