Results 71 to 80 of about 9,251,353 (260)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

High electrical conductivity and crystal structure of the solid oxide cell electrode Pr4Ni3O10-δ [PDF]

, 2020
Pr4Ni3O10-δ is a promising air electrode for solid oxide fuel cells and electrolysers with comparable performance to Pr2NiO4+δ but with improved thermodynamic stability at a cell operating temperature of 600 ​°C–800 ​°C. To fully understand and integrate
Tsai, Chen-Yu, Aguadero, Ainara, Skinner, Stephen   +2 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Influences of multi-pass friction stir alloying on characterization of AZ91D alloy-based dual reinforcement bio-ceramic nano-composites

Journal of Applied Biomaterials & Functional Materials
In current study, microstructural, mechanical and corrosion behaviour were investigated with incorporation of dual reinforced AZ91D surface composites. This research was carried out for enhancement of the bio-degradability in biological environment.
Surendra Kumar Patel, Guoxin Dai, Lu Liu, Zhen Sun, Lei Shi   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Heterocyclic Diradical Benzo-1,2:4,5-bis(1,3,2-dithiazolyl). Electronic, Molecular and Solid State Structure [PDF]

, 1997
The preparation and purification of the heterocyclic diradical benzo-1,2:4,5-bis(1,3,2-dithiazolyl) (BBDTA) is described. Crystals of BBDTA, grown by fractional sublimation at 120-180 °C/10-3 Torr, are monoclinic, space group P21/c, with a = 4.144(2), b =
Palstra, T.T.M.,, Oakley, R.T., Patenaude, G.W., Mawhinney, R.C.,, Reed, R.W.,, de Laat, R.H., Haddon, R.C., Laat, R.H. de,, Palstra, T.T.M., Patenaude, G.W.,, Goddard, J.D., Westwood, N.P.C., Jeter, D.Y.,, Barclay, T.M.,, Reed, R.W., Barclay, T.M., Cordes, A.W., Jeter, D.Y., Mawhinney, R.C., Westwood, N.P.C.,, Goddard, J.D.,, Haddon, R.C.,, Oakley, R.T.,, Cordes, A.W.,   +23 more
core   +3 more sources

Thermoelectric Characterization of Electronic Properties of GaMnAs Nanowires

Journal of Nanotechnology, 2012
Nanowires with magnetic doping centers are an exciting candidate for the study of spin physics and proof-of-principle spintronics devices. The required heavy doping can be expected to have a significant impact on the nanowires' electron transport ...
Phillip M. Wu, Waldomiro Paschoal, Sandeep Kumar, Christian Borschel, Carsten Ronning, Carlo M. Canali, Lars Samuelson, Håkan Pettersson, Heiner Linke   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source