Results 81 to 90 of about 9,251,353 (260)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

High pressure solid state chemistry of C-N-H and Ti-N systems [PDF]

open access: yes, 2010
This thesis presents the use of molecular precursors for the synthesis of solid-state materials through the application of extreme conditions. The main tool for the exploration of these materials was the diamond anvil cell which generated static ...
Salamat, N.
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Preparation and Solid State Characterization of 4,4'-Bis(1,2,3,5-dithiadiazolyl) [PDF]

open access: yes, 1994
The reaction of oxamidrazone with sulfur dichloride affords 4,4'-bis(1,2,3,5-dithiadiazolium) dichloride, which can be reduced with triphenylantimony to the corresponding bis(1,2,3,5-dithiadiazolyl) diradical; the solid state structure and transport ...
Hicks, Robin G.,   +13 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Towards zero solid waste: utilising tannery waste as a protein source for poultry feed [PDF]

open access: yes, 2013
Zero waste is now a strongly emerging issue for sustainable industrial development where minimisation and utilisation of waste are a priority in the leather industry.
Antunes, A Paula M   +4 more
core  

Bi-Functional Extension on Heterogeneous ORR/OER Catalysis with 2D Materials for Li-O2 Batteries

open access: yesNano-Micro Letters
Highlights This review systematically summarizes the catalytic performance of two-dimensional (2D) materials in Li–O2 batteries, together with activation strategies spanning point, line, plane, and bulk dimensions.
Guoliang Zhang   +6 more
doaj   +1 more source

Scalable, high performance, enzymatic cathodes based on nanoimprint lithography

open access: yesBeilstein Journal of Nanotechnology, 2015
Here we detail high performance, enzymatic electrodes for oxygen bio-electroreduction, which can be easily and reproducibly fabricated with industry-scale throughput.
Dmitry Pankratov   +6 more
doaj   +1 more source

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