Results 41 to 50 of about 8,266,387 (310)

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization [PDF]

, 1994
We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entire chromosomes with underrepresentation of chromosome 1 ...
Speicher, Michael R., Cremer, Thomas, Kovacs, Gyula, Störkel, S., Ried, Thomas, Schoell, B., Manoir, Stanislas du, Schröck, Evelin   +7 more
core   +1 more source

Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

npj Breast Cancer, 2021
Novel antibody-drug conjugates against HER2 are showing high activity in HER2-negative breast cancer (BC) with low HER2 expression (i.e., 1+ or 2+ and lack of ERBB2 amplification). However, the clinical and molecular features of HER2-low BC are yet to be
Francesco Schettini, Nuria Chic, Fara Brasó-Maristany, Laia Paré, Tomás Pascual, Benedetta Conte, Olga Martínez-Sáez, Barbara Adamo, Maria Vidal, Esther Barnadas, Aranzazu Fernández-Martinez, Blanca González-Farre, Esther Sanfeliu, Juan Miguel Cejalvo, Giuseppe Perrone, Giovanna Sabarese, Francesca Zalfa, Vicente Peg, Roberta Fasani, Patricia Villagrasa, Joaquín Gavilá, Carlos H. Barrios, Ana Lluch, Miguel Martín, Mariavittoria Locci, Sabino De Placido, Aleix Prat   +26 more
doaj   +1 more source

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

New England Journal of Medicine, 2020
BACKGROUND No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers.
D. Hong, M. Fakih, J. Strickler, J. Desai, G. Durm, G. Shapiro, G. Falchook, T. Price, A. Sacher, C. Denlinger, Y. Bang, G. Dy, J. Krauss, Y. Kuboki, J. Kuo, A. Coveler, Keunchil Park, T. W. Kim, F. Barlesi, P. Munster, S. Ramalingam, Timothy F. Burns, F. Meric-Bernstam, H. Henary, J. Ngang, G. Ngarmchamnanrith, June Kim, B. Houk, J. Canon, J. Lipford, G. Friberg, P. Lito, R. Govindan, Bob T. Li   +33 more
semanticscholar   +1 more source

Antibody–drug conjugates in solid tumors: a look into novel targets

Journal of Hematology & Oncology, 2021
Antibody–drug conjugates (ADCs) are a relatively new class of anticancer agents designed to merge the selectivity of monoclonal antibodies with cell killing properties of chemotherapy.
C. Criscitiello, S. Morganti, G. Curigliano   +2 more
semanticscholar   +1 more source

Feasibility of Photofrin II as a radiosensitizing agent in solid tumors - Preliminary results [PDF]

, 2006
Background: Photofrin II has been demonstrated to serve as a specific and selective radiosensitizing agent in in vitro and in vivo tumor models. We aimed to investigate the feasibility of a clinical application of Photofrin II.
Wilkowski, Ralf, Schaffer, Pamela Manuela, Ertl-Wagner, Birgit, Jori, Giulio, Kulka, Ulrike, Dühmke, Eckhart, Hofstetter, Anton, Schaffer, Moshe   +7 more
core   +1 more source

Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors

Innovation (Cambridge (Mass.))
Identifying genes with prognostic significance that can act as biomarkers in solid tumors can help stratify patients and uncover novel therapy targets.
B. Győrffy
semanticscholar   +1 more source

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Frontiers in Pharmacology, 2021
Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs.
Agnese Gagliardi, Elena Giuliano, Eeda Venkateswararao, M. Fresta, S. Bulotta, V. Awasthi, D. Cosco   +6 more
semanticscholar   +1 more source

Application of X-ray Microtomography to Quantify the Liquid Fraction of M2 Steel for Semi-solid Forming process [PDF]

, 2013
Thixoforging, one variant of semi-solid metal processing in which the metallic alloys are processed at low liquid fraction (0.1< Fl < 0.3), is used to produce complex parts with high mechanical properties.
GU, Guochao, LANGLOIS, Laurent, BECKER, Eric, PESCI, Raphaël, BIGOT, Régis   +4 more
core   +1 more source

FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis

Journal of Translational Medicine
Background Acute pancreatitis (AP) presents a significant clinical challenge with limited therapeutic options. The complex etiology and pathophysiology of AP emphasize the need for innovative treatments.
Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila   +18 more
doaj   +1 more source

Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival

Molecular Oncology, 2020
Development of precision medicine for malignant pleural mesothelioma (MPM) requires a deep knowledge of tumor heterogeneity. Histologic and molecular classifications and histo‐molecular gradients have been proposed to describe heterogeneity, but a deeper
Lisa Quetel, Clément Meiller, Jean‐Baptiste Assié, Yuna Blum, Sandrine Imbeaud, François Montagne, Robin Tranchant, Julien deWolf, Stefano Caruso, Marie‐Christine Copin, Véronique Hofman, Laure Gibault, Cécile Badoual, Ecaterina Pintilie, Paul Hofman, Isabelle Monnet, Arnaud Scherpereel, Françoise Le Pimpec‐Barthes, Jessica Zucman‐Rossi, Marie‐Claude Jaurand, Didier Jean   +20 more
doaj   +1 more source