Results 81 to 90 of about 8,266,387 (310)

Enzymatic Inactivation of Oxysterols in Breast Tumor Cells Constraints Metastasis Formation by Reprogramming the Metastatic Lung Microenvironment

Frontiers in Immunology, 2018
Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly ...
Marta A. Moresco, Marta A. Moresco, Laura Raccosta, Gianfranca Corna, Daniela Maggioni, Matias Soncini, Silvio Bicciato, Claudio Doglioni, Claudio Doglioni, Vincenzo Russo   +9 more
doaj   +1 more source

Advances in targeting histone deacetylase for treatment of solid tumors

Journal of Hematology & Oncology
Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention.
M. Shi, Ying Xu, Xin-Wen Fu, De-Si Pan, Xianping Lu, Yi Xiao, Yi-Zhou Jiang   +6 more
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Aerosolized BC-819 inhibits primary but not secondary lung cancer growth. [PDF]

, 2011
Despite numerous efforts, drug based treatments for patients suffering from lung cancer remains poor. As a promising alternative, we investigated the therapeutic potential of BC-819 for the treatment of lung cancer in mouse tumor models.
Corinna Pfeifer, Patricia Ohana, Wagner Kai, Carsten Rudolph, Aneja, Manish Kumar, Gilon, Michal, Hochberg, Avraham, Pfeifer, Corinna, Ohana, Patricia, Hasenpusch, Günther, Kai Wagner, Günther Hasenpusch, Gilon Michal, Ohana Patricia, Rudolph, Carsten, Michal Gilon, Hasenpusch Günther, Manish Kumar Aneja, Pfeifer Corinna, Avraham Hochberg, Reinhardt Dietrich, Wagner, Kai, Reinhardt, Dietrich, Aneja Manish Kumar, Hochberg Avraham, Rudolph Carsten, Dietrich Reinhardt   +26 more
core   +2 more sources

EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth

Journal of Hematology & Oncology, 2017
Background Activated protein C/endothelial protein C receptor (APC/EPCR) axis is physiologically involved in anticoagulant and cytoprotective activities in endothelial cells.
Naiara Perurena, Carolina Zandueta, Susana Martínez-Canarias, Haritz Moreno, Silvestre Vicent, Ana S. Almeida, Elisabet Guruceaga, Roger R. Gomis, Marta Santisteban, Mikala Egeblad, José Hermida, Fernando Lecanda   +11 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Sweet dreams could be made of this: carbohydrate‐responsive element‐binding protein (ChREBP) as a target for hepatocellular carcinoma therapy

Molecular Oncology
Rewiring of cellular metabolism is now fully recognized as a hallmark of cancer. Tumor cells reprogram metabolic pathways to meet the energetic and macromolecular demands to support unrestricted growth and survival under unfavorable conditions.
Maite G. Fernández‐Barrena, Matías A. Avila   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cutaneous side effects of molecularly targeted therapies for the treatment of solid tumors

, 2018
Background: Currently, molecularly targeted drugs are part of the therapeutic arsenal for the treatment of many neoplasms and are responsible for improvements in the quality of life and survival of patients.
Auro Del Giglio, Fabio Iazetti Lopes, Vanessa Salzano, Jose Guzman, Daniel I G Cubero, Jean Schoueri, Beatrice Martinez Zugaib Abdalla, Karine Corcione Turke, Carlos D’Apparecida Santos Machado Filho, Dolores Gonzalez Fabra   +9 more
core   +1 more source

Immune Regulation and the Role of Extracellular Vesicles in Non-Small Cell Lung Cancer: Biological Mechanisms and Therapeutic Perspectives

Pharmaceuticals
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) representing the most common subtype.
Nicole Ferrario, Orazio Fortunato, Patrizia Ghidotti   +2 more
doaj   +1 more source