Results 11 to 20 of about 760,353 (358)

Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma

Disease Models & Mechanisms, 2022
There is a paucity of adequate mouse models and cell lines available to study lung squamous cell carcinoma (LUSC). We have generated and characterized two models of phenotypically different transplantable LUSC cell lines, i.e.
Karmele Valencia, Cristina Sainz, Cristina Bértolo, Gabriel de Biurrun, Jackeline Agorreta, Arantza Azpilikueta, Marta Larrayoz, Graziella Bosco, Carolina Zandueta, Miriam Redrado, Esther Redín, Francisco Exposito, Diego Serrano, Mirari Echepare, Daniel Ajona, Ignacio Melero, Ruben Pio, Roman Thomas, Alfonso Calvo, Luis M. Montuenga   +19 more
doaj   +1 more source

Immunotherapy for Solid Tumors

Cancers, 2023
The development of immune checkpoint inhibitors (ICIs) constitutes a major therapeutic advance in the treatment of a number of malignancies [...]
Hortense de Saint Basile, Zineb Maaradji, Elizabeth Fabre   +2 more
openaire   +2 more sources

Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling

Cell Death and Disease, 2023
Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their ...
Ilaria Petraroia, Patrizia Ghidotti, Giulia Bertolini, Francesca Pontis, Luca Roz, Melissa Balsamo, Paola Suatoni, Ugo Pastorino, Anna Maria Ferretti, Gabriella Sozzi, Orazio Fortunato   +10 more
doaj   +1 more source

SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation

Journal for ImmunoTherapy of Cancer, 2021
Introduction The use of immune-checkpoint inhibitors has drastically improved the management of patients with non-small cell lung cancer (NSCLC), but innate and acquired resistances are hurdles needed to be solved.
Jackeline Agorreta, Ana Remirez, Ruben Pio, Luis M Montuenga, Teresa Lozano, Esther Redin, Irati Garmendia, Diego Serrano, Yaiza Senent, Miriam Redrado, Maria Villalba, Francisco Exposito, Daniel Ajona, Sergio Ortiz-Espinosa, Cristina Bertolo, Cristina Sainz, Juana Garcia-Pedrero, Juan Lasarte, Alfonso Calvo   +18 more
doaj   +1 more source

Improving high-resolution copy number variation analysis from next generation sequencing using unique molecular identifiers

BMC Bioinformatics, 2021
Background Recently, copy number variations (CNV) impacting genes involved in oncogenic pathways have attracted an increasing attention to manage disease susceptibility.
Pierre-Julien Viailly, Vincent Sater, Mathieu Viennot, Elodie Bohers, Nicolas Vergne, Caroline Berard, Hélène Dauchel, Thierry Lecroq, Alison Celebi, Philippe Ruminy, Vinciane Marchand, Marie-Delphine Lanic, Sydney Dubois, Dominique Penther, Hervé Tilly, Sylvain Mareschal, Fabrice Jardin   +16 more
doaj   +1 more source

Gene expression profiles of breast cancer metastasis according to organ site

Molecular Oncology, 2022
In advanced breast cancer, biomarker identification and patient selection using a metastatic tumor biopsy is becoming more necessary. However, the biology of metastasis according to the organ site is largely unknown.
Fara Brasó‐Maristany, Laia Paré, Nuria Chic, Olga Martínez‐Sáez, Tomás Pascual, Meritxell Mallafré‐Larrosa, Francesco Schettini, Blanca González‐Farré, Esther Sanfeliu, Débora Martínez, Patricia Galván, Esther Barnadas, Belinda Salinas, Pablo Tolosa, Eva Ciruelos, Esther Carcelero, Cecilia Guillén, Barbara Adamo, Reinaldo Moreno, Maria Vidal, Montserrat Muñoz, Aleix Prat   +21 more
doaj   +1 more source

Mechanobiology of solid tumors

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2022
Mechanical features of cancer cells emerge as a distinct trait during development and progression of solid tumors. Herein, we discuss recent key findings regarding the impact of various types of mechanical stresses on cancer cell properties. Data suggest that different mechanical forces, alterations of matrix rigidity and tumor microenvironment ...
Gargalionis, A.N., Papavassiliou, K.A., Papavassiliou, A.G.   +2 more
openaire   +3 more sources

Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood

Bioengineering & Translational Medicine, 2022
The analysis of circulating tumor cells (CTCs) in blood is a powerful noninvasive alternative to conventional tumor biopsy. Inertial‐based separation is a promising high‐throughput, marker‐free sorting strategy for the enrichment and isolation of CTCs ...
Alejandro Rodríguez‐Pena, Estibaliz Armendariz, Alvaro Oyarbide, Xabier Morales, Sergio Ortiz‐Espinosa, Borja Ruiz‐Fernández de Córdoba, Denis Cochonneau, Iñaki Cornago, Dominique Heymann, Josepmaría Argemi, Delia D'Avola, Bruno Sangro, Fernando Lecanda, Ruben Pio, Iván Cortés‐Domínguez, Carlos Ortiz‐de‐Solórzano   +15 more
doaj   +1 more source

Glomangiomyoma of the knee : a rare juxtasynovial presentation [PDF]

, 2020
Glomus tumors are benign tumors typically located in the subcutis or deep dermis of the subungual region of the fingers. Histologically, glomus tumors are divided into three subtypes, in descending order of frequency: solid glomus tumor, glomangioma and ...
De Backer, Adelard, Hustings, Nico, Vanhoenacker, Filip   +2 more
core   +1 more source

Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels

Gels, 2021
Understanding how cancer cells migrate, and how this migration is affected by the mechanical and chemical composition of the extracellular matrix (ECM) is critical to investigate and possibly interfere with the metastatic process, which is responsible ...
Xabier Morales, Iván Cortés-Domínguez, Carlos Ortiz-de-Solorzano   +2 more
doaj   +1 more source