Results 171 to 180 of about 457,366 (268)

Ionizing radiation enhances CAR T-cell infiltration and efficacy in solid tumors. [PDF]

Front Immunol
Zhan L, Clark MA, Loos P, Lee CM, Paulus LER, Shi R, Sekhon PK, Piret JM, Evgin L, Bennewith KL.   +9 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

The LNK adaptor protein: a dual regulator of proliferation and migration in solid tumors. [PDF]

Mol Cell Oncol
Mantilla-Ollarves JC, Velazquez L, Rocha-Zavaleta L.   +2 more
europepmc   +1 more source

Solid Tumors [PDF]

Bone Marrow Transplantation, 2002
openaire   +1 more source

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Exploiting the dynamics of hyperthermia-enhanced delivery of thermosensitive liposomal doxorubicin to solid tumors. [PDF]

Drug Deliv
Namakshenas P, Crezee J, Kok HP.
europepmc   +1 more source

A Naphthalimide‐Based NIR‐Emissive AIE Photosensitizer for Synergistic Apoptosis/Ferroptosis‐Mediated Antitumor Therapy and Broad‐Spectrum Bacterial Inactivation With Rapid Wound Healing

Advanced Healthcare Materials, EarlyView.
An ionic naphthalimide AIE photosensitizer (PS), TPAPV‐NIM‐M, anchors to cellular and bacterial membranes, emits in the far‐red/near‐infrared (NIR) region, and efficiently generates reactive oxygen species (ROS) under white light. Its membrane‐localized photodynamic action drives apoptosis/ferroptosis‐mediated tumor suppression and broad‐spectrum ...
Sayed Mir Sayed, Zeeshan Tahir, Fahri Alkan, Yavuz Nuri Ertas   +3 more
wiley   +1 more source

Successful autologous T cell apheresis in pediatric patients with hematologic malignancies, solid tumors, and brain tumors. [PDF]

Cytotherapy
Murphy D, Bi Y, Patel A, Li Y, Zheng Y, Poston L, Akel S, Kilpatrick C, Lockey T, Zhou S, Bertrand KC, DeRenzo C, Naik S, Sharma A, Talleur AC, Velasquez MP, Triplett BM, Gottschalk S, Selukar S, Epperly R.   +19 more
europepmc   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Supercharging the metabolic engine: mitochondrial engineering strategies for CAR-T persistence in solid tumors. [PDF]

Front Immunol
Chun S, Yu S, Lee HG, Kim MS.
europepmc   +1 more source