Results 121 to 130 of about 456,204 (268)

Landscape of T-cell engagers in solid tumors. [PDF]

Oncologist
Garcia-Lorenzo E, Dorta M, Doger B, Pedregal M, Moreno V.   +4 more
europepmc   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Utility of Ultra-Low-Pass Whole Genome Sequencing in Bile CfDNA for the Management of Patients With Biliary Strictures

The Journal of Liquid Biopsy, 2023
M. Arechederra, C. Rojo, M. Rullán, M. Elizalde, J. Herranz, D. Oyón, J. Argemí, J. Urman, M. Ávila, C. Berasain   +9 more
doaj   +1 more source

CAR-M Therapy: From Concept to Clinical Translation in Solid Tumors. [PDF]

Cells
Miao C, Chen Z, Chen J, Sun J, Sun Y, Shi W, Xu W, Li Y, Zhao X.   +8 more
europepmc   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

A new perspective on immune evasion: escaping immune surveillance by inactivating tumor suppressors

Signal Transduction and Targeted Therapy, 2022
Svenja Mergener, Samuel Peña-Llopis
doaj   +1 more source

Generation of functional canine TIL products for solid tumors. [PDF]

Front Immunol
Foos KM, Pandey V, Jennings MW, Powell DJ, Mason NJ.   +4 more
europepmc   +1 more source

Gellan Gum Fluid Gel System for Controlled‐Delivery of Cytokine‐Licensed MSC‐EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency

Advanced Healthcare Materials, EarlyView.
Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh, Ava Dashti, Thomas E. Robinson, Robyn Gaffey, Richard Moakes, Neil Lagali, Liam Grover, Thomas Ritter   +7 more
wiley   +1 more source

Targeting Bruton’s Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challenges

Drug Design, Development and Therapy
Sebastian Torke,1,* Sarah Dybowski,2,* Martin S Weber2– 41Experimental and Clinical Research Center, Charité-Medical Center Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany; 2Department of Neurology, University ...
Torke S, Dybowski S, Weber MS
doaj  

Plying potency assays for immunotherapy of solid tumors. [PDF]

Front Immunol
Burns JS, Gjeta R, Lesný P, Vives J.
europepmc   +1 more source