Results 171 to 180 of about 11,159 (266)

“I teach her at home”: Home learning environments amid resource constraints

open access: yesFamily Relations, EarlyView.
ABSTRACT Objective This study examined how mothers with low incomes think about and enact investments of time and money for their infants and toddlers. Background Infancy and toddlerhood are pivotal years for development. Home learning environments in these earliest years can also set the stage for later home learning environments.
Jill Hoiting, Sarah Halpern‐Meekin
wiley   +1 more source

Gaming behavior changes in families: Mothers and children during the COVID‐19 pandemic

open access: yesFamily Relations, EarlyView.
ABSTRACT Objective We examined changes in gaming behavior among families with young children during the COVID‐19 pandemic and their association with pre‐pandemic media use types and family climate. Background The pandemic reshaped families' mediatized daily lives.
Simone Schüller   +4 more
wiley   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

open access: yesThe FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi   +8 more
wiley   +1 more source

Molecular dynamics simulations and fluorescence spectroscopy suggest reduced tryptophan‐to‐heme energy transfer facilitates lignin degradation in ClassII peroxidases

open access: yesThe FEBS Journal, EarlyView.
In lignin peroxidase and versatile peroxidase, low FRET from buried Trp to heme promotes long‐range electron transfer (LRET) from substrate to heme. This efficient electron flow is facilitated by reduced FRET competition. This mechanism likely evolved to enable the effective degradation of bulky, high‐redox‐potential lignin that cannot reach the enzyme'
Yi Ren   +6 more
wiley   +1 more source

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