Results 121 to 130 of about 492,620 (298)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Characterization of abiotic conditions affecting vegetation distribution in the river Plate coastal plain, Argentina = Caracterização das condições abióticas que influem na distribuição da vegetação na planície costeira do rio de la Plata, Argentina

Acta Scientiarum: Biological Sciences, 2008
The river Plate coastal plain is located in northeastern Buenos Airesprovince, where geological events such as sea transgressions and regressions in the Holocene have produced a stratigraphic column with marine-estuarine, fluviatile and continental ...
Jorge Eloy Giménez, Martín Adolfo Hurtado, Omar Raúl Martínez   +2 more
doaj  

Contribuição para a elaboração da carta de solos da cidade de Bragança [PDF]

, 2009
Este trabalho teve como objectivo dar um contributo para o estudo dos solos existentes no perímetro urbano da Cidade de Bragança. Estudo este integrado na elaboração do Plano Verde da cidade.
Afonso, Natália, Arrobas, Margarida
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Utilização do sistema de avaliação do potencial de uso urbano das terras no diagnóstico ambiental do município de Santa Maria - RS

Ciência Rural, 2006
A expansão urbana acelerada tem provocado diversos impactos negativos ao ambiente. A necessidade de novas metodologias que permitam um planejamento mais adequado dos recursos naturais é cada dia mais evidente.
Pedron Fabrício de Araújo, Dalmolin Ricardo Simão Diniz, Azevedo Antonio Carlos de, Poelking Everton Luis, Miguel Pablo   +4 more
doaj  

Caracterização morfológica de solos sódicos em diferentes paleodiques no pantanal norte. [PDF]

, 2014
O Pantanal é considerado a maior planície continental inundável do mundo, englobando diferentes habitats, sustentando grande diversidade vegetal e de solos, se destacando os solos sódicos (Planossolos e Luvissolos).
BEIRIGO, R. M., CHIAPIN, M., FURQUIM, S. A. C., NASCIMENTO, A. F. do, OLIVEIRA JUNIOR, J. C. de O., VIDAL-TORRADO, P.   +5 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Parâmetros de consistência dos solos: seu estudo e avaliação ao longo de perfis pedológicos para aplicação na engenharia rodoviária. [PDF]

, 2012
Foram estudados os limites de consistencia dos solos ao longo de perfis pedologicos para aplicacao na engenharia rodoviaria. As amostras foram coletadas de horizontes superficiais e subsuperficiais em dez perfis de diferentes classes de solos.
OLMOS ITURRI LARACH, J., SOUZA, J. L. R. de   +1 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source