Results 141 to 150 of about 58,709 (306)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Anais [...]. [PDF]

, 2017
A primeira reunião da RedeMDS foi realizada na Embrapa Solos, Rio de Janeiro, no período de 21 a 24 de novembro de 2011 e contou com a participação de 32 membros de 12 instituições.
REUNIÃO DA REDE BRASILEIRA DE PESQUISA EM MAPEAMENTO DIGITAL DE SOLOS, 1., 2011, Rio de Janeiro.
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

DSM para regiões e países com limitada infraestrutura de dados espaciais de solos. [PDF]

, 2014
DSM está se tornando um importante tema na maioria dos países, com impacto positivo sobre os levantamentos de solos, por meio da melhoria no mapeamento de classes e propriedades dos solos e predição, para subsidiar o planejamento do uso das terras, o ...
CAPECHE, C. L., SANTOS, H. G. dos, MENDONÇA-SANTOS, M. de L., PRADO, R. B., FIDALGO, E. C. C., RAMALHO FILHO, A.   +5 more
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Si no estoy solo, puedo solo

, 2008
ESP
openaire   +2 more sources

Variáveis ambientais e a distribuição de espécies arbóreas em um remanescente de floresta estacional semidecídua montana no campus da Universidade Federal de Lavras, MG

Acta Botânica Brasílica, 2002
Este trabalho teve como objetivo detectar padrões de distribuição espacial da comunidade arbórea de um fragmento de floresta estacional semidecídua montana e suas relações com variáveis ambientais, com ênfase nas variações catenárias do solo e efeito das
Espírito-Santo Fernando Del Bon, Oliveira-Filho Ary Teixeira de, Machado Evandro Luiz Mendonça, Souza Josival Santos, Fontes Marco Aurélio Leite, Marques João José Granate de Sá Melo   +5 more
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Solos do município de Água Branca: estado de Alagoas. [PDF]

, 2015
O presente trabalho refere-se a uma sinopse de levantamento de reconhecimento de média intensidade de solos, que constitui parte do Projeto de Zoneamento Agroecológico do Estado de Alagoas, tendo como menores células territoriais os municípios.
LEITE, A. P., OLIVEIRA NETO, M. B. de, PARAHYBA, R. da B. V.   +2 more
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