Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
THE SOLUBILITY-PRODUCT CONSTANT OF CALCIUM AND MAGNESIUM CARBONATES. [PDF]
, 1915 John Johnston
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Reactivity in decision-form games [PDF]
In this paper we introduce the reactivity in decision-form games. The concept of reactivity allows us to give a natural concept of rationalizable solution for decision-form games: the solubility by elimination of sub- reactive strategies. This concept of
Carfì, David
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Solubility of mercurous sulphate in sulphuric-acid solutions
, 1936 D. Norman Craig +2 more
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THE SOLUBILITY OF SILVER CHLORIDE IN CHLORIDE SOLUTIONS AND THE EXISTENCE OF COMPLEX ARGENTICHLORIDE IONS. [PDF]
, 1911 George S. Forbes
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Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
HISTOCHEMICAL LOCALIZATION OF SPECIFIC OXIDATIVE ENZYMES. IV. SOLUBLE OXIDATION-REDUCTION DYES AS AIDS IN THE HISTOCHEMICAL LOCALIZATION OF OXIDATIVE ENZYMES WITH TETRAZOLIUM SALTS [PDF]
, 1956 Emmanuel Farber, CONNIE D. LOUVIERE
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Development of new techniques for the characterization of crystals and their growth solutions: Center director's discretionary fund [PDF]
The solubility measurement system and the laser scattering microscope system were designed, built, and utilized for the study of crystal growth solutions and crystal characterization measurements. Solubility measurements and crystal defect maps were made
Kroes, Roger L., Reiss, Donald A.
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Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source