Results 241 to 250 of about 1,049,628 (364)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Carbon dioxide solubility in polyethylene glycol polymer: an accurate intelligent estimation framework. [PDF]

Sci Rep
Sead FF, Sur D, Yadav A, Ballal S, Singh A, Krithiga T, Vats S, Yuldashev F, Ahmad I, Sherzod S.   +9 more
europepmc   +1 more source

FAT-SOLUBLE VITAMINS

, 1925
H. Steenbock, A. Black, Mariana T. Nelson, C.A. Hoppert, Blanche M. Riising   +4 more
openalex   +1 more source

INDIRECT MEASUREMENTS OF THE ROTATORY POWERS OF SOME ALPHA AND BETA FORMS OF THE SUGARS BY MEANS OF SOLUBILITY EXPERIMENTS. [PDF]

, 1917
C. S. Hudson, E. Yanovsky
openalex   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

Advanced analysis on the correlation of salicylic acid solubility to solvent composition, temperature and pressure via machine learning approach. [PDF]

Sci Rep
Mahdi WA, Alhowyan A, Obaidullah AJ.
europepmc   +1 more source

THE CUTANEOUS REACTION TO SOLUBLE ANTIGEN-ANTIBODY COMPLEXES [PDF]

, 1958
Charles G. Cochrane, William O. Weigle
openalex   +1 more source

The soluble length of soluble linear groups

Mathematische Zeitschrift, 1972
openaire   +2 more sources

Solubility Enhancement Of Poorly Soluble Drug

The purpose of this evaluation was to enhance the solubility and bioavailability of poorly soluble medications through a variety of methods such as physical, chemical, and other modifications or techniques. Solubility refers to the maximum amount of solute that can dissolve in a specific amount of solvent or solution at a given temperature.
openaire   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source