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Solubility of sparingly-soluble ionizable drugs
Advanced Drug Delivery Reviews, 2007The experimental and computational basis of the pH-dependent measurement of solubility of sparingly-soluble ionizable drugs is reviewed. Recently described compound-sparing (but still accurate) approaches, suitable for application in preclinical development, and appropriate for the analysis of solubility of "problematic" molecules, are critically ...
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Scandinavian Journal of Clinical and Laboratory Investigation, 2011
CD163 is an endocytic receptor for haptoglobin-hemoglobin complexes and is expressed solely on macrophages and monocytes. As a result of ectodomain shedding, the extracellular portion of CD163 circulates in blood as a soluble protein (sCD163) at 0.7-3.9 mg/l in healthy individuals.
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CD163 is an endocytic receptor for haptoglobin-hemoglobin complexes and is expressed solely on macrophages and monocytes. As a result of ectodomain shedding, the extracellular portion of CD163 circulates in blood as a soluble protein (sCD163) at 0.7-3.9 mg/l in healthy individuals.
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Solubility, solvency, and solubility parameters
Industrial & Engineering Chemistry Product Research and Development, 1985Approche du parametre de solubilite a trois composants afin de predire le degre de solubilisation et la solubilite/insolubilite des ...
John W. Van Dyk +2 more
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Are solubilities and solubility products related?
Journal of Chemical Education, 1966The relation between solubilities and solubility products is far less intimate than is stated or implied by introductory texts and the ideas and calculations involved are too complex for presentation on the elementary level.
Louis Meites +2 more
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Solubility of the Least-Soluble Asphaltenes
2007The key to understanding many asphaltene-related phenomena is a quantitative description of the solubility conditions at which the least-soluble asphaltenes begin to flocculate from a crude oil, often referred to as the onset of flocculation. Models that treat asphaltene flocculation as a liquid–liquid phase separation of large solute molecules ...
Jill S. Buckley +2 more
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Solubility and partitioning I: Solubility of nonelectrolytes in water
Journal of Pharmaceutical Sciences, 1980On the basis of a semiempirical analysis, an equation was obtained that enables the estimation of the aqueous solubility of either liquid or crystalline organic nonelectrolytes: (see formula in text) where log PC and delta Sf are estimated from the chemical structure and MP is either known or experimentally determined.
S H, Yalkowsky, S C, Valvani
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