Targeting Soluble Guanylyl Cyclase during Ischemia and Reperfusion. [PDF]
Cells, 2023 Ischemia and reperfusion (IR) damage organs and contribute to many disease states. Few effective treatments exist that attenuate IR injury. The augmentation of nitric oxide (NO) signaling remains a promising therapeutic target for IR injury. NO binds to soluble guanylyl cyclase (sGC) to regulate vasodilation, maintain endothelial barrier integrity, and
Mace EH +3 more
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GAPDH delivers heme to soluble guanylyl cyclase. [PDF]
J Biol Chem, 2020 Soluble guanylyl cyclase (sGC) is a key component of NO-cGMP signaling in mammals. Although heme must bind in the sGC β1 subunit (sGCβ) for sGC to function, how heme is delivered to sGCβ remains unknown. Given that GAPDH displays properties of a heme chaperone for inducible NO synthase, here we investigated whether heme delivery to apo-sGCβ involves ...
Dai Y +4 more
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Soluble guanylyl cyclase activation promotes angiogenesis [PDF]
BMC Pharmacology, 2005 Two commonly accepted features of soluble guanylyl cyclase (sGC): its lack of "partners" and its exclusive-cytoplasmic localization were recently challenged. Several proteins that bind directly to sGC have now been identified. The molecular chaperone Hsp70 is one of these sGCinteracting proteins.
Pyriochou, Anastasia +3 more
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Redox regulation of soluble guanylyl cyclase. [PDF]
Nitric Oxide, 2018 The nitric oxide/soluble guanylyl cyclase (NO-sGC) signaling pathway regulates the cardiovascular, neuronal, and gastrointestinal systems. Impaired sGC signaling can result in disease and system-wide organ failure. This review seeks to examine the redox control of sGC through heme and cysteine regulation while discussing therapeutic drugs that target ...
Shah RC +4 more
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Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase. [PDF]
J Biol Chem, 2021 Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an amplifier in NO-driven biological signaling cascades. Because sGC helps regulate the cardiovascular, neuronal, and gastrointestinal systems through its cGMP production ...
Stuehr DJ, Misra S, Dai Y, Ghosh A.
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Soluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress. [PDF]
Redox Biol, 2022 Cui C +5 more
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Expression of soluble guanylyl cyclase [PDF]
FEBS Letters, 1990 Purified soluble guanylyl cyclase consists of two subunits (70 and 73 kDa) whose primary structures were recently determined. The availability of cDNA clones coding for either subunit allowed to study the question of the functional roles of the two subunits in expression experiments.
Christian Harteneck +4 more
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Inactivation of soluble guanylyl cyclase in living cells proceeds without loss of haem and involves heterodimer dissociation as a common step. [PDF]
Br J Pharmacol, 2022 Dai Y, Stuehr DJ.
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Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries. [PDF]
Int J Mol Sci, 2021 Zhong C +11 more
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Structure/function of the soluble guanylyl cyclase catalytic domain. [PDF]
Nitric Oxide, 2018 Soluble guanylyl cyclase (GC-1) is the primary receptor of nitric oxide (NO) in smooth muscle cells and maintains vascular function by inducing vasorelaxation in nearby blood vessels. GC-1 converts guanosine 5'-triphosphate (GTP) into cyclic guanosine 3',5'-monophosphate (cGMP), which acts as a second messenger to improve blood flow.
Childers KC, Garcin ED.
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