Soluble Guanylyl Cyclase Activators-Promising Therapeutic Option in the Pharmacotherapy of Heart Failure and Pulmonary Hypertension. [PDF]
Molecules, 2023 Endogenous nitric oxide (NO)-dependent vascular relaxation plays a leading role in the homeostasis of the cardiovascular, pulmonary, and vascular systems and organs, such as the kidneys, brain, and liver.
Grześk G +6 more
europepmc +3 more sources
Targeting Soluble Guanylyl Cyclase during Ischemia and Reperfusion. [PDF]
Cells, 2023 Ischemia and reperfusion (IR) damage organs and contribute to many disease states. Few effective treatments exist that attenuate IR injury. The augmentation of nitric oxide (NO) signaling remains a promising therapeutic target for IR injury.
Mace EH +3 more
europepmc +4 more sources
GAPDH delivers heme to soluble guanylyl cyclase. [PDF]
J Biol Chem, 2020 Soluble guanylyl cyclase (sGC) is a key component of NO–cGMP signaling in mammals. Although heme must bind in the sGC β1 subunit (sGCβ) for sGC to function, how heme is delivered to sGCβ remains unknown.
Dai Y +4 more
europepmc +6 more sources
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase. [PDF]
J Biol Chem, 2021 Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an amplifier in NO-driven biological signaling cascades. Because sGC helps regulate the cardiovascular, neuronal, and gastrointestinal systems through its cGMP production ...
Stuehr DJ, Misra S, Dai Y, Ghosh A.
europepmc +5 more sources
Cellular Factors That Shape the Activity or Function of Nitric Oxide-Stimulated Soluble Guanylyl Cyclase. [PDF]
Cells, 2023 NO-stimulated guanylyl cyclase (SGC) is a hemoprotein that plays key roles in various physiological functions. SGC is a typical enzyme-linked receptor that combines the functions of a sensor for NO gas and cGMP generator.
Sharina I, Martin E.
europepmc +5 more sources
Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action in vitro and in vivo. [PDF]
Front Mol Biosci, 2022 Nitric oxide (NO), carbon monoxide (CO), oxygen (O2), hydrogen sulfide (H2S) are gaseous molecules that play important roles in the physiology and pathophysiology of eukaryotes.
Wu G, Sharina I, Martin E.
europepmc +5 more sources
Redox regulation of soluble guanylyl cyclase. [PDF]
Nitric Oxide, 2018 The nitric oxide/soluble guanylyl cyclase (NO-sGC) signaling pathway regulates the cardiovascular, neuronal, and gastrointestinal systems. Impaired sGC signaling can result in disease and system-wide organ failure. This review seeks to examine the redox control of sGC through heme and cysteine regulation while discussing therapeutic drugs that target ...
Shah RC +4 more
europepmc +5 more sources
Structure/function of the soluble guanylyl cyclase catalytic domain. [PDF]
Nitric Oxide, 2018 Soluble guanylyl cyclase (GC-1) is the primary receptor of nitric oxide (NO) in smooth muscle cells and maintains vascular function by inducing vasorelaxation in nearby blood vessels. GC-1 converts guanosine 5'-triphosphate (GTP) into cyclic guanosine 3',5'-monophosphate (cGMP), which acts as a second messenger to improve blood flow.
Childers KC, Garcin ED.
europepmc +5 more sources
Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation. [PDF]
Nat Cardiovasc Res, 2022 Aim The role of platelets in atherosclerosis remains incompletely understood. Variants in genes encoding the soluble guanylyl cyclase (sGC) in platelets are associated with coronary artery disease (CAD) risk.
Mauersberger C +18 more
europepmc +2 more sources
Age Impairs Soluble Guanylyl Cyclase Function in Mouse Mesenteric Arteries. [PDF]
Int J Mol Sci, 2021 Endothelial dysfunction (ED) comes with age, even without overt vessel damage such as that which occurs in atherosclerosis and diabetic vasculopathy. We hypothesized that aging would affect the downstream signalling of the endothelial nitric oxide (NO ...
Zhong C +11 more
europepmc +2 more sources