Results 101 to 110 of about 30,038 (314)

Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases [PDF]

, 2014
A
Bracke, Ken, Brouckaert, Peter, Brusselle, Guy, Dupont, Lisa, Glynos, Constantinos   +4 more
core   +2 more sources

Real-time imaging of cGMP signaling shows pronounced differences between glomerular endothelial cells and podocytes

Scientific Reports
Recent clinical trials of drugs enhancing cyclic guanosine monophosphate (cGMP) signaling for cardiovascular diseases have renewed interest in cGMP biology within the kidney.
Nelli Rutkowski, Frederik Görlitz, Eva Wiesner, Julia Binz-Lotter, Susanne Feil, Robert Feil, Thomas Benzing, Matthias J. Hackl   +7 more
doaj   +1 more source

Localization of soluble guanylyl cyclase in the superficial dorsal horn [PDF]

Journal of Comparative Neurology, 2006
AbstractNitric oxide (NO) has been implicated in pain processing at the spinal level, but the mechanisms mediating its effects remain unclear. In the present work, we studied the organization of the major downstream effector of NO, soluble guanylyl cyclase (sGC), in the superficial dorsal horn of rat.
Jindong Ding, Richard J. Weinberg
openaire   +3 more sources

Rationale and design of the FAIR‐HF2‐DZHK05 trial: Ferric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure

European Journal of Heart Failure, Volume 27, Issue 4, Page 681-689, April 2025.
Study overview describing the intravenous iron supplementation protocol during the repletion and the maintenance phases, duration of follow‐up, and the three co‐primary endpoints. CV, cardiovascular, HF, heart failure; TSAT, transferrin saturation.
Stefan D. Anker, Tim Friede, Javed Butler, Khawaja M. Talha, Monika Diek, Anna Nosko, Marius Placzek, Gerd Hasenfuß, Piotr Ponikowski, Mahir Karakas   +9 more
wiley   +1 more source

Fluorescent Fusion Proteins of Soluble Guanylyl Cyclase Indicate Proximity of the Heme Nitric Oxide Domain and Catalytic Domain [PDF]

, 2010
BACKGROUND: To examine the structural organisation of heterodimeric soluble guanylyl cyclase (sGC) Förster resonance energy transfer (FRET) was measured between fluorescent proteins fused to the amino- and carboxy-terminal ends of the sGC beta1 and alpha
A Periasamy, AJ Lembo, AM Bamberger, B Wedel, C Rothkegel, DC Youvan, DL Garbers, DS Karow, EM Boon, G Schultz, GH Patterson, HH Schmidt, HH Schmidt, JA Winger, JA Winger, Jan Robert Kraehling, K Truong, LM Iyer, M Elangovan, M Koglin, M Koglin, M Ormo, Marcelo G. Bonini, N Haase, Nadine Haase, NB Fernhoff, OV Evgenov, P Nioche, R Efendiev, RY Tsien, Soenke Behrends, T Förster, T Shiga, T Sorkina, TK Kerppola, Tobias Haase, U Zabel, V Anantharaman, VL Kolossov, VO Nikolaev, X Ma, X Ma, X Ma, Y Zhao, Y Zhao, YC Lee   +45 more
core   +7 more sources

Some results on the solubility graph of a finite group [PDF]

arXiv, 2023
Let $G$ be a finite insoluble group with soluble radical $ R(G)$. The solubility graph $\Gamma_{\rm S}(G)$ of $G$ is a simple graph whose vertices are the elements of $G\setminus R(G) $ and two distinct vertices $x$ and $y$ are adjacent if and only if they generate a soluble subgroup of $G$.
arxiv  

Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism. [PDF]

PLoS ONE, 2011
There is clearly a necessity to identify novel non-dopaminergic mechanisms as new therapeutic targets for Parkinson's disease (PD). Among these, the soluble guanylyl cyclase (sGC)-cGMP signaling cascade is emerging as a promising candidate for second ...
Kuei Y Tseng, Adriana Caballero, Alexander Dec, Daryn K Cass, Natalie Simak, Elizabeth Sunu, Michael J Park, Shannon R Blume, Stephen Sammut, Diana J Park, Anthony R West   +10 more
doaj   +1 more source

Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules

Exploration, Volume 5, Issue 2, April 2025.
This project develops a biomimetic stent coating with a double presentation of therapeutic biomacromolecule VEGF and therapeutic gas NO, which spatiotemporally promotes vessel repair including promoting rapid re‐endothelialization, effectively preventing thrombosis, suppressing inflammation and restenosis.
Jingdong Rao, Di Suo, Qing Ma, Yongyi Mo, Ho‐Pan Bei, Li Wang, Chuyang Y. Tang, Kai‐Hang Yiu, Shuqi Wang, Zhilu Yang, Xin Zhao   +10 more
wiley   +1 more source

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Molecules, 2014
Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension.
Renata Galvão de Lima, Bruno Rodrigues Silva, Roberto Santana da Silva, Lusiane Maria Bendhack   +3 more
doaj   +1 more source

Is L‐Arginine an Appropriate Alternative for Conventional Anti‐Atherosclerotic Therapy?: A Comprehensive Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background Atherosclerosis is the leading cause of cardiovascular disease (CVD). Historically, the management of atherosclerosis was focused on decreasing lipid profile levels; however, recent evidence demonstrated that platelets and leukocytes play an important role in forming and exacerbating atherosclerosis.
Ali Mortezaei, Mohammad Ghorbani, Bardia Hajikarimloo, Omar Sameer, Toba Kazemi, Ebrahim Salavati, Mohsen Hamidpour, Mohammad Esmail Gheydari   +7 more
wiley   +1 more source