Role of the soluble guanylyl cyclase 1 subunit in mice corpus cavernosum smooth muscle relaxation [PDF]
, 2008 C
Brouckaert, Peter +5 more
core +1 more source
Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease [PDF]
, 2020 Nitric oxide (NO)-cyclic GMP (cGMP) signaling is a vasoprotective pathway therapeutically targeted, for example, in pulmonary hypertension. Its dysregulation in disease is incompletely understood.
Deile, Martin +7 more
core +2 more sources
Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways. Overexposure to epinephrine inactivates adenylate-cyclase,a causal pathway for stress-pathologies [PDF]
BioSystems 100 (2010) p. 87-93, 2010 Incubation with noradrenaline (norepinephrine) of isolated membranes of rat's brain corpus striatum and cortex, showed that ionic-magnesium (Mg2+) is required for the neurotransmitter activatory response of Adenylate Cyclase [ATP pyrophosphate-lyase (cyclizing), (EC 4.6.1.1)], AC.An Mg2+-dependent response to the activatory effects of adrenaline, and ...
arxiv
β-Amyloid Peptides Decrease Soluble Guanylyl Cyclase Expression in Astroglial Cells
Neurobiology of Disease, 2002 In astroglial cells β-amyloid peptides (βA) induce a reactive phenotype and increase expression of NO synthase. Here we show that treatment of rat brain astrocytes with βA decreases their capacity to accumulate cyclic GMP (cGMP) in response to NO as a ...
Marı́a Antonia Baltrons +3 more
doaj
AJP - Renal Physiology, 2016 Activators of soluble guanylyl cyclase (sGC) interact directly with its prosthetic heme group, enhancing the enzyme responsiveness in pathological conditions.
M. D. de Oliveira +5 more
semanticscholar +1 more source
Recent Advances in Mammalian Olfactory Receptor Function and Structure
Sensory Neuroscience, Volume 1, Issue 1, April 2025.Olfactory receptors (ORs), a subset of G protein‐coupled receptors (GPCRs), mediate odor detection in sensory neurons and regulate diverse physiological functions across tissues. Their roles in metabolism, immunity, and neural processes underscore their therapeutic relevance. Recent high‐resolution Cryo‐EM studies have unveiled OR activation mechanisms,
Hongxi Qin +9 more
wiley +1 more source
Multiple lineage specific expansions within the guanylyl cyclase gene family [PDF]
, 2006 BACKGROUND: Guanylyl cyclases (GCs) are responsible for the production of the secondary messenger cyclic guanosine monophosphate, which plays important roles in a variety of physiological responses such as vision, olfaction, muscle contraction ...
Burnell, Ann M +2 more
core +3 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.Given the established association between obstructive sleep apnea‐hypopnea syndrome (OSAHS) and neurodegenerative pathogenesis, this review systematically investigates the mechanisms by which chronic intermittent hypoxia (CIH) contributes to OSAHS‐related neural injury.
Nan‐Nan Jia +7 more
wiley +1 more source
Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase [PDF]
, 2010 Background The soluble guanylyl cyclase (sGC) is a heterodimeric enzyme that, upon activation by nitric oxide, stimulates the production of the second messenger cGMP.
Beuve, Annie +2 more
core +3 more sources
Localizations of finitely generated soluble groups [PDF]
arXiv, 2010 The study of localizations of groups has concentrated on group theoretic properties which are preserved by localization. In this paper we look at finitely generated soluble groups and determine when the local groups associated with them are soluble.
arxiv