Results 121 to 130 of about 30,038 (314)

Solubility of organic salts in solvent-antisolvent mixtures: A combined experimental and molecular dynamics simulations approach [PDF]

arXiv, 2022
We combine molecular dynamics simulations with experiments to estimate solubilities of organic salts in complex growth environments. We predict the solubility by simulations of the growth and dissolution of ions at the crystal surface kink sites at different solution concentrations.
arxiv  

Inhibition of cGMP‐Signalling Rescues Retinal Ganglion Cells From Axotomy‐Induced Degeneration

Journal of Neurochemistry, Volume 169, Issue 4, April 2025.
Retinal ganglion cell (RGC) axons are myelinated only beyond the lamina cribrosa, that is, when leaving the eye. Axotomy‐induced RGC degeneration is likely to be related to excessive nitric oxide (NO) production, leading to an over‐production of cGMP, over‐activation of protein kinase G (PKG) and excessive phosphorylation of target proteins, such as ...
Katia Ihadadene, Azdah Hamed A Fallatah, Yu Zhu, Arianna Tolone, François Paquet‐Durand   +4 more
wiley   +1 more source

Membrane guanylate cyclase, a multimodal transduction machine: history, present, and future directions [PDF]

, 2014
A sequel to these authors’ earlier comprehensive reviews which covered the field of mammalian membrane guanylate cyclase (MGC) from its origin to the year 2010, this article contains 13 parts.
Rameshwar K. Sharma, Teresa Duda
core   +3 more sources

The Inhibitory Mechanism of YC-1, a Benzyl Indazole, on Smooth Muscle Cell Proliferation: an In Vitro and In Vivo Study

Journal of Pharmacological Sciences, 2004
The pharmacological mechanisms of a synthetic compound 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) in preventing smooth muscle cell proliferation remains to be elucidated.
Chieh-Hsi Wu, Weng-Cheng Chang, Gee-Yat Chang, Sheng-Chu Kuo, Che-Ming Teng   +4 more
doaj  

Decoding the role of large heat shock proteins in the progression of neuroinflammation‐mediated neurodegenerative disorders

Neuroprotection, Volume 3, Issue 1, Page 48-62, March 2025.
This article summarizes the complex role of heat shock proteins (HSPs) in neurodegenerative disease progression. Several brain regions such as the hippocampus, cortex, basal ganglia, and brain stem are affected in diverse neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and multiple sclerosis.
Shailendra K. Saxena, Deepak Sharma, Swatantra Kumar, Vimal K. Maurya, Saniya Ansari, Hardeep S. Malhotra, Amit Singh   +6 more
wiley   +1 more source

From synaptically localized to volume transmission by nitric oxide. [PDF]

, 2016
Nitric oxide (NO) functions widely as a transmitter/diffusible second messenger in the central nervous system, exerting physiological effects in target cells by binding to specialized guanylyl cyclase-coupled receptors, resulting in cGMP generation ...
Garthwaite, J
core   +1 more source

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

eLife, 2020
Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure.
Sophie Schobesberger, Peter T Wright, Claire Poulet, Jose L Sanchez Alonso Mardones, Catherine Mansfield, Andreas Friebe, Sian E Harding, Jean-Luc Balligand, Viacheslav O Nikolaev, Julia Gorelik   +9 more
doaj   +1 more source

Potassium channel‐mediated NO‐induced vasodilation during maturation: Dominance of Kv7 channels

FASEB BioAdvances, Volume 7, Issue 3, March 2025.
Scheme illustrating the key findings: Potassium channels, even multiple ones, contribute to SNP‐induced vasorelaxation in young and adult rats and these channels change from Kv1 and Kv7 channels to BKCa and Kv7 channels during postnatal development.
Anastasia A. Shvetsova, Dina K. Gaynullina, Peter Winkler, Paulus Wohlfart, Rudolf Schubert   +4 more
wiley   +1 more source

8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one

Molbank, 2011
8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[
Andrey A. Berezin, Panayiotis A. Koutentis   +1 more
doaj   +1 more source

Cross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons

British Journal of Pharmacology, Volume 182, Issue 5, Page 1236-1253, March 2025.
Abstract Background and Purpose Acetylcholine plays a key role in striatal function. Firing properties of striatal cholinergic interneurons depend on intracellular cAMP through the regulation of Ih currents. Yet, the dynamics of cyclic nucleotide signalling in these neurons have remained elusive.
Ségolène Bompierre, Yelyzaveta Byelyayeva, Elia Mota, Marion Lefevre, Anna Pumo, Jan Kehler, Liliana R. V. Castro, Pierre Vincent   +7 more
wiley   +1 more source