Results 151 to 160 of about 30,038 (314)
Molecular variants of soluble guanylyl cyclase affecting cardiovascular risk.
Circulation Journal, 2015 Soluble guanylyl cyclase (sGC) is the physiological receptor for nitric oxide (NO) and NO-releasing drugs, and is a key enzyme in several cardiovascular signaling pathways. Its activation induces the synthesis of the second messenger cGMP. cGMP regulates
J. Wobst +5 more
semanticscholar +1 more source
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase [PDF]
, 2008 Background Soluble guanylate cyclases generate cyclic GMP when bound to nitric oxide, thereby linking nitric oxide levels to the control of processes such as vascular homeostasis and neurotransmission. The guanylate cyclase catalytic module, for which no
Derbyshire, Emily R +4 more
core +3 more sources
Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells. [PDF]
, 1994 Karl‐Wilhelm Koch +4 more
openalex +1 more source
Targeting soluble guanylyl cyclase in experimental Parkinsonism
The FASEB Journal, 2010 Alterations in striatal cyclic nucleotide homeostasis are apparent following loss of dopamine (DA) innervation and may contribute to pathophysiological changes observed in basal ganglia circuits in Parkinson's disease (PD). This study examined the utility of systemic administration of the soluble guanylyl cyclase (sGC) inhibitor [1H‐[1,2,4] oxadiazolo‐[
Stephen Sammut +6 more
openaire +1 more source
Critical Care Research and Practice, 2012 The heme-protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide (NO). sGC is a heterodimeric enzyme with α and β subunits and contains a heme moiety essential for binding of NO and activation of the enzyme.
Bobby Nossaman +2 more
doaj +1 more source
Vascular nitric oxide: Beyond eNOS
Journal of Pharmacological Sciences, 2015 As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources
Yingzi Zhao +2 more
doaj +1 more source
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase [PDF]
, 1998 Michael Russwurm +3 more
openalex +1 more source
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases [PDF]
, 1998 The active sites of guanylyl and adenylyl cyclases are closely related. The crystal structure of adenylyl cyclase and modeling studies suggest that specificity for ATP or GTP is dictated in part by a few amino acid residues, invariant in each family ...
Beuve, A. +5 more
core +1 more source
On locally defined formations of soluble Lie and Leibniz algebras [PDF]
arXiv, 2011 It is well-known that all saturated formations of finite soluble groups are locally defined and, except for the trivial formation, have many different local definitions. I show that for Lie and Leibniz algebras over a field of characteristic 0, the formations of all nilpotent algebras and of all soluble algebras are the only locally defined formations ...
arxiv
Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
Frontiers in Neuroscience, 2019 PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms +2 more
doaj +1 more source