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Role of SOLUBLE GUANYLYL CYCLASE in RENAL AFFERENT AND EFFERENT ARTERIOLES.
AJP - Renal Physiology, 2020Renal arteriolar tone depends considerably on the dilatory action of nitric oxide (NO) via activation of soluble guanylyl cyclase (sGC) and cGMP action.
I. C. Wennysia +12 more
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Distribution of soluble guanylyl cyclase in rat retina
Journal of Comparative Neurology, 2006AbstractThe nitric oxide (NO)‐cGMP pathway is implicated in modulation of visual information processing in the retina. Despite numerous functional studies of this pathway, information about the retinal distribution of the major downstream effector of NO, soluble guanylyl cyclase (sGC), is very limited.
Richard J. Weinberg, Jindong Ding
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Soluble Guanylyl Cyclases [PDF]
, 1996 In addition to phospholipases, NO synthases and adenylyl cyclases which synthesize lipid second messengers, NO and cAMP respectively, guanylyl cyclases are also capable of production of the potent transducer molecule cyclic GMP.
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The effect of hypercholesterolemia on platelet soluble guanylyl cyclase
Vascular Pharmacology, 2003We sought to determine whether hypercholesterolemia impacts on the NO-stimulated activity of platelet soluble guanylyl cyclase (sGC). We investigated two groups of nine New Zealand white rabbits receiving either a standard (NC) or a cholesterol chow (HC, 0.75%) for 15 weeks.
Georg Kojda +2 more
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Regulation of nitric oxide and soluble guanylyl cyclase
Brain Research Bulletin, 2004Since the discoveries that have verified nitric oxide (NO) as an endogenously produced cell signaling molecule, research surrounding its production and mechanisms of action have been studied at an exponentially increasing rate. NO is produced by a family of enzymes termed the NO synthases (NOS), which are regulated independently by various stimuli ...
Khalid A. Hanafy +2 more
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Enzymology of Soluble Guanylyl Cyclase
2000Soluble guanylyl cyclase (sGC) probably represents the most important receptor for nitric oxide (NO) as a signalling molecule (Fig. 1). The enzyme catalyses the conversion of guanosine triphosphate (GTP) into guanosine cyclic monophosphate (cGMP). Activation of sGC by NO leads to an enormous stimulation of cGMP production, yielding an up to 400-fold ...
A. Friebe, D. Koesling
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Molecular aspects of soluble guanylyl cyclase regulation
General Pharmacology: The Vascular System, 2000Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme (comprised of alpha and beta subunits) that generates the intracellular second messenger cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). cGMP is subsequently important for the regulation of protein kinases, ion channels, and phosphodiesterases.
Andreas Papapetropoulos +1 more
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Cardiovascular Research, 2018
AIMS Aged arteries are characterized by attenuated vasodilator and enhanced vasoconstrictor responses, which contribute to the development of diseases such as arterial hypertension, atherosclerosis, and heart failure.
Yumeng Guo +8 more
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AIMS Aged arteries are characterized by attenuated vasodilator and enhanced vasoconstrictor responses, which contribute to the development of diseases such as arterial hypertension, atherosclerosis, and heart failure.
Yumeng Guo +8 more
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Functions of Conserved Cysteines of Soluble Guanylyl Cyclase
Biochemistry, 1997Soluble guanylyl cyclase (sGC), a heme-containing heterodimeric enzyme, is stimulated by NO and catalyzes the formation of the intracellular signaling molecule cGMP. Cysteine residues of sGC have been considered to be important as they were thought to play a significant role in the regulation of the enzyme.
John Foerster +5 more
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