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Soluble Guanylyl Cyclase Activation Promotes Angiogenesis
The Journal of Pharmacology and Experimental Therapeutics, 2006Soluble guanylyl cyclase (sGC) is a cGMP-generating enzyme carrying a heme prosthetic group that functions as a nitric oxide (NO) sensor. sGC is present in most cells types, including the vascular endothelium, where its biological functions remain largely unexplored.
Anastasia Pyriochou +6 more
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Distribution of soluble guanylyl cyclase in the rat brain
Journal of Comparative Neurology, 2004AbstractThe diffusible messenger nitric oxide (NO) acts in the brain largely through activation of soluble guanylyl cyclase (sGC), a heterodimer comprising α and β subunits. We used immunohistochemistry to study the distribution of both sGC subunits in the brain of adult rats.
Richard J. Weinberg +4 more
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A-350619: A novel activator of soluble guanylyl cyclase
Life Sciences, 2003Nitric oxide (NO) is a key mediator in many physiological processes and one of the major receptors through which NO exerts its effects is soluble guanylyl cyclase. Guanylyl cyclase converts GTP to cyclic GMP as part of the cascade that results in physiological processes such as smooth muscle relaxation, neurotransmission, inhibition of platelet ...
Robert B. Moreland +6 more
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Soluble guanylyl cyclase: more secrets revealed
Cellular Signalling, 2005Guanylyl cyclases (GCs) are enzymes that convert guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophosphate (cGMP). The second messenger cGMP participates in signaling by (1) stimulating the activity of kinases that belong to the protein kinase G family, (2) altering the conductance of cGMP-gated ion channels and (3) changing the activity ...
Andreas Papapetropoulos +1 more
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Regulation of soluble guanylyl cyclase: looking beyond NO
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006neurotransmission, platelet function, skeletal muscle and vascular and nonvascular smooth muscle, and numerous other cellular functions are significantly regulated by the principal enzyme initially transducing nitric oxide (NO) signals, soluble guanylyl cyclase (sGC) ([8][1]). The better-
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Soluble Guanylyl Cyclase: The Nitric Oxide Receptor
2005Soluble guanylyl cyclase is recognized as the most sensitive physiologic receptor for nitric oxide. Binding of nitric oxide to the heme moiety of the cyclase induces its capacity to synthesize the second messenger cGMP. Although the changes in the state of the heme moiety upon exposure of enzyme to NO and its correlation to the stimulation of sGC ...
Emil Martin +3 more
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Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells
Biochemical and Biophysical Research Communications, 2014Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and generates the second messenger cyclic GMP (cGMP). Recently, purified sGC α1β1 has been shown to additionally generate the cyclic pyrimidine nucleotides cCMP and cUMP. However, since cyclic pyrimidine nucleotide formation occurred only the presence of Mn(2+) but not Mg(2+), the ...
Heike Bähre +4 more
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Measurement of cGMP and Soluble Guanylyl Cyclase Activity
Current Protocols in Toxicology, 1999AbstractSoluble guanylyl cyclase is responsible for synthesis of guanosine 3'5'‐cyclic monophosphate. The enzyme is activated by NO, so measurement of tissue levels of cGMP and the activity of guanylyl cyclase is important in studies of NO‐cGMP signal transduction.
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Studying the Structure and Regulation of Soluble Guanylyl Cyclase
Methods, 1999Soluble guanylyl cyclase acts as the receptor for the signaling molecule nitric oxide. The enzyme consists of two different subunits. Each subunit shows the cyclase catalytic domain, which is also conserved in the membrane-bound guanylyl cyclases and the adenylyl cyclases.
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Hemoglobin mediated nitrite activation of soluble guanylyl cyclase
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2005Nitrite has long been known to be vasoactive when present at large concentrations but it was thought to be inactive under physiological conditions. Surprisingly, we have recently shown that supraphysiological and near physiological concentrations of nitrite cause vasodilation in the human circulation.
Xiuli Xu +6 more
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