Results 41 to 50 of about 30,038 (314)
Nucleotidyl cyclase activity of recombinant soluble guanylyl cyclase [PDF]
BMC Pharmacology, 2009 The ubiquitously expressed soluble guanylyl cyclase(sGC) converts guanosine 5'-triphosphate (GTP) to gua-nosine 3':5'-cyclic monophosphate (cGMP). The het-erodimeric protein is activated by nitric oxide (NO). sGCplays a key role in the regulation of vascular tone and neu-rotransmission.
Volkhard Kaever +3 more
openaire +2 more sources
Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction. [PDF]
PLoS ONE, 2015 Soluble guanylyl cyclase (sGC) is a heterodimeric nitric oxide (NO) receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system.
Erin J Heckler +5 more
doaj +1 more source
Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer [PDF]
Current Biology, 1999 Guanylyl cyclases (GCs), the enzymes that synthesize cyclic GMP (cGMP), have classically been divided into two groups: receptor GCs and soluble GCs. Receptor GCs are integral membrane proteins such as the retinal guanylyl cyclases and the atrial natriuretic peptide receptors.
Elizabeth Waters +3 more
openaire +3 more sources
Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose. [PDF]
PLoS ONE, 2012 The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase α(1)β(1) synthesize the cyclic pyrimidine nucleotide cCMP.
Andreas Hammerschmidt +9 more
doaj +1 more source
Acta Physiologica, 2020 Natriuretic peptides, BNP and ANP increase renal blood flow in experimental animals. The signalling pathway in human kidney vasculature is unknown. It was hypothesized that BNP and ANP cause endothelium‐independent relaxation of human intrarenal arteries
A. Frees +9 more
semanticscholar +1 more source
Guanylyl cyclase activation reverses resistive breathing–induced lung injury and inflammation [PDF]
, 2015 Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces lung injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway is down-regulated in chronic and acute animal models of RB, such as ...
Brouckaert, Peter +15 more
core +2 more sources
British Journal of Pharmacology, 2020 Heart failure is associated with an impaired NO–soluble guanylyl cyclase (sGC)–cGMP pathway and its augmentation is thought to be beneficial for its therapy.
Julia Rüdebusch +10 more
semanticscholar +1 more source
Newly identified NO-sensor guanylyl cyclase/connexin 43 association is involved in cardiac electrical function [PDF]
, 2017 Background: Guanylyl cyclase, a heme-containing alpha 1 beta 1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO-GC1-cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac ...
Beuve, Annie +7 more
core +2 more sources
Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1 [PDF]
, 2023 The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands.
Beuve, Annie +12 more
core +2 more sources
Cardiovascular Diabetology, 2012 Background Adiposity greatly increases the risk of atherothrombotic events, a pathological condition where a chronic state of oxidative stress is reported to play a major role.
Monteiro Priscila F +7 more
doaj +1 more source