Results 71 to 80 of about 30,038 (314)
Peptide B targets soluble guanylyl cyclase α1 and kills prostate cancer cells.
PLoS ONE, 2017 Among androgen-regulated genes, soluble guanylyl cyclase α1 (sGCα1) is significant in promoting the survival and growth of prostate cancer cells and does so independent of nitric oxide (NO) signaling.
Jun Zhou +4 more
doaj +1 more source
Does soluble guanylyl cyclase need a chaperone? [PDF]
BMC Pharmacology, 2005 Two commonly accepted features of soluble guanylyl cyclase (sGC): its lack of "partners" and its exclusive-cytoplasmic localization were recently challenged. Several proteins that bind directly to sGC have now been identified. The molecular chaperone Hsp70 is one of these sGCinteracting proteins.
Nazish Sayed +4 more
openaire +2 more sources
Frontiers in Pharmacology, 2012 Nitric oxide (NO) is a potent dilator of vascular smooth muscle (VSM) by modulating intracellular cGMP ([cGMP]i) through the binding and activation of receptor guanylyl cylases (sGC).
Kara F. Held +2 more
doaj +1 more source
Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]
, 2020 The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands.
Beuve, Annie +12 more
core +2 more sources
The commuting graph of a soluble group [PDF]
, 2012 The commuting graph of a finite soluble group with trivial centre is investigated. It is shown that the diameter of such a graph is at most 8 or the graph is disconnected. Examples of soluble groups with trivial centre and commuting graph of diameter 8 are provided.
arxiv +1 more source
Amyloid Fibril Solubility [PDF]
J. Phys. Chem. B, 2015, 119 (46), pp 14631-14636, 2015 It is well established that amyloid fibril solubility is protein specific, but how solubility depends on the interactions between the fibril building blocks is not clear. Here we use a simple protein model and perform Monte Carlo simulations to directly measure the solubility of amyloid fibrils as a function of the interaction between the fibril ...
arxiv +1 more source
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain [PDF]
, 2009 In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death.
Garthwaite, J., Hall, C.N., Keynes, R.G.
core +3 more sources
Cardiovascular Effects of Modulators of Soluble Guanylyl Cyclase Activity [PDF]
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2008 Soluble guanylyl cyclase (sGC) is one of the key enzymes of the nitric-oxide (NO)/cyclic 3',5'-guanosine monophosphate (cGMP) pathway. Located in virtually all mammalian cells, it controls the vessel tone, smooth muscle cell growth, platelet aggregation, and leukocyte adhesion.
Hoenicka, Markus, Schmid, Christof
openaire +4 more sources
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]
, 2018 Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
core +2 more sources