Results 141 to 150 of about 460,443 (348)

Structure-function relationships for the IL 2-receptor system. IV. Analysis of the sequence and ligand-binding properties of soluble Tac protein. [PDF]

, 1987
R J Robb, Rusty Kutny
openalex   +1 more source

The IL-2 - IL-2 receptor pathway in health and disease: the role of the soluble IL-2 receptor.

Clinical Immunology, 2020
J. Damoiseaux
semanticscholar   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, Volume 15, Issue 5, Page 699-713, May 2025.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Clinical Remission Criteria and Serum Levels of Type 2 Inflammation Mediators during 24 Weeks of Treatment with the Anti-IL-5 Drug Mepolizumab in Patients with T2-High Severe Asthma

Diagnostics
Anti-interleukin (IL) 5 is an effective treatment modality for inhibiting eosinophilic inflammation in patients with T2-high severe asthma. The aim of this study was to determine the clinical efficacy and serum levels of type 2 inflammatory mediators ...
Jolita Palacionyte, Andrius Januskevicius, Egle Vasyle, Airidas Rimkunas, Skaidrius Miliauskas, Kestutis Malakauskas   +5 more
doaj   +1 more source

Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma

Mediators of Inflammation, 1995
The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects ...
G. Di Lorenzo, P. Mansueto, M. Melluso, G. Morici, F. Norrito, D. Cigna, G. Candore, C. Caruso   +7 more
doaj   +1 more source

1012 SOLUBLE INTERLEUKIN-2 RECEPTORS (IL-2R) ARE PRODUCED BY ACTIVATED CORD BLOOD CELLS IN VITRO [PDF]

, 1985
David L. Nelson, Carole C. Kurman, Bernard Boutin, Laurence A. Rubin   +3 more
openalex   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, Volume 15, Issue 5, Page 738-753, May 2025.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists

Respiratory Research, 2001
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus ...
Borish Larry, Steinke John W
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas. [PDF]

, 1997
Vladimir Kolenko, Qing Wang, M.C. Riedy, John J. O’Shea, Jerome Ritz, Martha K. Cathcart, Patricia Rayman, R Tubbs, Mark Edinger, A Novick, Ronald Bukowski, Jürgen Finke   +11 more
openalex   +1 more source