Results 301 to 310 of about 460,443 (348)

Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario, Lorenzo Moroni, Carlos Mota   +2 more
wiley   +1 more source

Soluble Triggering Receptors on Myeloid Cells-1 Could Be a Potential Biomarker for Disease Activity in Familial Mediterranean Fever. [PDF]

J Clin Lab Anal
Cemiloglu M, Ozcan O, Kimyon G, Arpaci A, Oguzman H.   +4 more
europepmc   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Analysis and interpretation of inflammatory fluid markers in Alzheimer's disease: a roadmap for standardization. [PDF]

J Neuroinflammation
Bettcher BM, de Oliveira FF, Willette AA, Michalowska MM, Machado LS, Rajbanshi B, Borelli WV, Tansey MG, Rocha A, Suryadevara V, Hu WT.   +10 more
europepmc   +1 more source

Salt‐Compact Albumin as a New Pure Protein‐based Biomaterials: From Design to In Vivo Studies

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
A new class of materials built entirely of native albumin protein is designed using a simple protocol based on salt‐assisted compaction, breaking with current crosslinking strategies. This green process leads, surprisingly, to water‐insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that ...
Eya Aloui, Jordan Beurton, Claire Medemblik, Ludivine Hugoni, Igor Clarot, Ariane Boudier, Youri Arntz, Marcella De Giorgi, Jérôme Combet, Guillaume Fleith, Eric Mathieu, Naji Kharouf, Leyla Kocgozlu, Benoît Heinrich, Damien Favier, Michael Brender, Fouzia Boulmedais, Pierre Schaaf, Benoît Frisch, Philippe Lavalle   +19 more
wiley   +1 more source

The role of IL-6 in thyroid eye disease: an update on emerging treatments. [PDF]

Front Ophthalmol (Lausanne)
Murdock J, Nguyen J, Hurtgen BJ, Andorfer C, Walsh J, Lin A, Tubbs C, Erickson K, Cockerham K.   +8 more
europepmc   +1 more source

Pincer‐Type Pt(II)‐NHC Antibody‐Drug Conjugate for HER‐2‐Targeted Chemoimmunotherapy

Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
The antibody‐drug conjugate Trastuzumab‐Pt1 has demonstrated successful development as a targeted therapeutic strategy for human epidermal growth factor receptor (HER‐2) high‐expression tumors. This innovative approach enables the efficient delivery of the cytotoxic payload Pt‐1 to mitochondria, thereby synergistically inducing necroptosis and ...
Tao Huang, Wan‐Qiong Huang, Gui‐Feng Huang, Xiao‐Long Wei, Yong‐Liang Huang, Tao Liu, Yungen Liu, Wen‐Xiu Ni, Chi‐Ming Che   +8 more
wiley   +1 more source

Comparative Structure Activity Relationship Characterization of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab. [PDF]

BioDrugs
Liu Y, Xie J, Li Z, Mei X, Cao D, Li S, Engle L, Liu S, Ebbers HC, Liu C.   +9 more
europepmc   +1 more source

The clinicopathological implications of serum IL-33 and sST2 as cancer biomarkers: A narrative review. [PDF]

J Oral Biol Craniofac Res
Acharya S, Hegde U, Acharya AB.
europepmc   +1 more source

Serum Soluble Asialoglycoprotein Receptor 1: A Potential Predictor Marker Linked to Type 2 Diabetes Mellitus, Demonstrating Positive Correlation With High Sensitive C-Reactive Protein. [PDF]

Diabetes Metab Syndr Obes
Zhu H, Zhong Z, Zhao G, Cao Y, Liu W, Guo Y, Jin J.   +6 more
europepmc   +1 more source