The weakest link bridging germinal center B cells and follicular dendritic cells limits antibody affinity maturation [PDF]
BioEssays, 2021, 2020 The affinity of antibodies (Abs) produced in vivo for their target antigens (Ags) is typically well below the maximum affinity possible. Nearly 25 years ago, Foote and Eisen explained how an 'affinity ceiling' could arise from constraints associated with the acquisition of soluble antigen by B cells.
arxiv +1 more source
MIXED LYMPHOCYTE REACTION-INDUCED RELEASE OF SOLUBLE IL-2 RECEPTOR
Transplantation, 1991 We studied the release of soluble interleukin 2 receptor (sIL-2R) by PBMC in mixed lymphocyte reaction (MLR) in order to clarify the significance of high plasma levels of sIL-2R in transplant patients undergoing rejection.
Dimitrios Degiannis +4 more
openalex +2 more sources
The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. [PDF]
PLoS Pathogens, 2005 Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage recognition receptor is critical for innate immunity to A ...
Chad Steele +7 more
doaj +2 more sources
Monitoring oligomerization dynamics of individual human neurotensin receptors 1 in living cells and in SMALP nanodiscs [PDF]
arXiv, 2023 The human neurotensin receptor 1 (NTSR1) is a G protein-coupled receptor. The receptor is activated by a small peptide ligand neurotensin. NTSR1 can be expressed in HEK cells by stable transfection. Previously we used the fluorescent protein markers mRuby3 or mNeonGreen fused to NTSR1 for EMCCD-based structured illumination microscopy (SIM) in living ...
arxiv
IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
Nature Communications, 2019 Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells.
Alyse L. Frisbee +12 more
doaj +1 more source
Journal of Neuroinflammation, 2011 Background Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior.
Johnson Rodney W +2 more
doaj +1 more source
Immunological recovery in patients with pulmonary tuberculosis after intensive phase treatment
Journal of International Medical Research, 2018 Objectives This study aimed to examine the change and significance of immune parameters in patients with sputum smear-positive pulmonary tuberculosis (TB) after 2 months of intensive phase anti-TB treatment.
Xuejiao Luo +4 more
doaj +1 more source
Cytokine units of immunoregulation of diabetic-associated osteoarthritis
Клінічна та профілактична медицина, 2020 Joint damage in patients with diabetes mellitus (DM) is a common complication and is associated with the induction of metabolic inflammation against the background of increased catabolic processes in various joint structures.
V.L. Orlenko
doaj +1 more source
Soluble ST2 levels and left ventricular structure and function in patients with metabolic syndrome [PDF]
, 2016 Background: A biomarker that is of great interest in relation to adverse cardiovascular events is soluble ST2 (sST2), a member of the interleukin family.
Beunza, Maite +14 more
core +1 more source
Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]
, 2020 β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik +4 more
core +2 more sources