Results 51 to 60 of about 460,443 (348)
Original paper Predictors of juvenile idiopathic arthritis course
Rheumatology, 2015 Introduction : Juvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases of joints in children with various and often unfavourable prognosis.
Jaryna J. Bojko +2 more
doaj +1 more source
Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice. [PDF]
PLoS ONE, 2012 A strong association exists between mutations at the IL2 receptor alpha chain (CD25) gene locus and susceptibility to a number of T cell driven autoimmune diseases.
Shane E Russell +3 more
doaj +1 more source
Role of IL-33 in inflammation and disease [PDF]
, 2011 Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
core +3 more sources
Physiological Reports, 2019 Background The immune system generates inflammatory responses through cytokines like Interleukin 6 (IL‐6) and the Tumor Necrosis Factor alpha (TNF α); these cytokines mediate cellular responses aided by the presence of soluble receptors such as: Soluble ...
Henry H. León‐Ariza +3 more
doaj +1 more source
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection
Viruses, 2015 The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies
Yaqin Zhou, Ying Zhu
doaj +1 more source
Frontiers in Immunology, 2019 The common gamma chain (γc) contributes to the formation of different cytokine receptors [e.g., IL-2 receptor (IL-2R), IL-7R, and IL-15R], which are important for generation of self-reactive T-cells in autoimmune diseases, like in type 1 diabetes (T1D ...
Julia Seyfarth +8 more
doaj +1 more source
Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5
FEBS Letters, Volume 599, Issue 6, Page 866-875, March 2025.The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu +4 more
wiley +1 more source
Relationship between serum level of interleukin-2 in patients with systemic lupus erythematosus and disease activity in comparison with control group [PDF]
, 2014 Background: Despite the large number of surveys, there are not any validated biomarkers for SLE disease activity till now. This study aimed to evaluate the relationship between serum level of IL-2 in patients with SLE and disease activity in comparison ...
Sedighi, S. +3 more
core +1 more source
Binding cooperativity of membrane adhesion receptors [PDF]
, 2009 The adhesion of cells is mediated by receptors and ligands anchored in apposing membranes. A central question is how to characterize the binding affinity of these membrane-anchored molecules. For soluble molecules, the binding affinity is typically quantified by the binding equilibrium constant K3D in the linear relation [RL] = K3D [R][L] between the ...
arxiv +1 more source
Grid-free stochastic simulations of reaction-diffusion processes at cell-cell contacts [PDF]
arXiv, 2023 Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce local morphological features or reorganizations of the membrane-associated or membrane-proximal biochemistry. Examples
arxiv