Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]
Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Matt Cotten +5 more
core +1 more source
Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway [PDF]
Gene-based therapies for a variety of inherited and acquired pulmonary diseases will require the development of vectors capable of safe and efficient transfer of DNA to the respiratory epithelium.
Boucher, R. C. +14 more
core +1 more source
Objective: To assess the association between genetic variants of transferrin receptor 2 (TFR2) exon 4 and anemia status and to describe the expression levels of several cytokines, hepcidin, soluble transferrin receptor and erythropoietin.
Dono Indarto +7 more
doaj +1 more source
TRANSFERRIN RECEPTOR EXPRESSION IN ORAL TUMORS [PDF]
Transferrin receptor expression in oral tumors was examined by staining with monoclonal antibody against the human transferrin receptor. The cells with positive reaction were recognized in the basal and parabasal layers of the normal epithelium.
Nobuyuki, TANAKA +6 more
core +1 more source
Soluble Transferrin Receptor - Ferritin Indices as Diagnostic Tool for Iron Deficiency Anemia in Chronic Kidney Disease in Children [PDF]
Background: Anemia is common complication in childern with chronic kidney disease (CKD) mainly anemia of chronic disease (ACD), but iron deficiency anemia (IDA) is also common.
Esraa Hassan +3 more
doaj +1 more source
Background Information on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association ...
Yanna Zhu +3 more
doaj +1 more source
DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety [PDF]
We have previously demonstrated that transferrin-polycation conjugates are efficient carrier molecules for the introduction of genes into eucariotic cells.
Mechtler, Karl +4 more
core +1 more source
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors
Background Currently used indicators of iron status have limitations. Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency. We sought to determine the properties of hepcidin as a diagnostic test of iron deficiency.Design and ...
Sant-Rayn Pasricha +6 more
doaj +1 more source
Methods to assess iron and iodine status [PDF]
Four methods are recommended for assessment of iodine nutrition: urinary iodine concentration, the goitre rate, and blood concentrations of thyroid stimulating hormone and thyroglobulin.
Zimmermann, Michael B. +2 more
core +1 more source
Association Between Iron Status and Risk of Chronic Kidney Disease in Chinese Adults
Background: Even though it is well-known that iron deficiency is the result of chronic kidney disease (CKD), whether iron will affect kidney function and disease in the general population is not clear. We thus conducted a nationwide cross-sectional study
Yongjian Zhu +9 more
doaj +1 more source

