Results 121 to 130 of about 3,560,062 (313)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Finite BCI-groups are solvable [PDF]

open access: yesInternational Journal of Group Theory, 2016
‎Let $S$ be a subset of a finite group $G$‎. ‎The bi-Cayley graph ${rm BCay}(G,S)$ of $G$ with respect to $S$ is an undirected graph with vertex set $Gtimes{1,2}$ and edge set ${{(x,1),(sx,2)}mid xin G‎, ‎ sin S}$‎. ‎A bi-Cayley graph ${rm BCay}(G,S)$ is
Majid Arezoomand, Bijan Taeri
doaj  

Compensating for imperfections in solvable chaotic oscillators [PDF]

open access: yesAIP Advances
We show a method to compensate for a class of implementation imperfections in a solvable chaotic oscillator while maintaining an analytic solution. We demonstrate the method by compensating for propagation delay in an electronic circuit realization of ...
Micah P. Tseng   +3 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Exact Solutions, Critical Parameters and Accidental Degeneracy for the Hydrogen Atom in a Spherical Box

open access: yesPhysics
This paper for the first time derives some properties of the hydrogen atom inside a box with an impenetrable wall. Scaling of the Hamiltonian operator proves to be practical for the derivation of some general properties of the eigenvalues.
Francisco M. Fernández
doaj   +1 more source

The C*-Algebras of Completely Solvable Lie Groups are Solvable

open access: yesJournal of Lie Theory
We prove that if a connected and simply connected Lie ...
Beltita, Ingrid, Beltita, Daniel
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Home - About - Disclaimer - Privacy